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Ubiquitin D (UBD)

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UB-D; FAT10; UBD-3; Diubiquitin; Ubiquitin-like protein FAT10

Ubiquitin D (UBD)
CCC B744
HGNC 18795
MGI 1344410
PubMed 19808075
RGD 69418
UniProt O15205
Wiki Ubiquitin_D

Ubiquitin D is a protein encoded by the UBD gene.Using selective cDNA hybridization of a YAC containing the HLA-F locus  region on chromosome 6, followed by Southern and Northern blot analyses, Fan et al. (1996) isolated a cDNA, which they called 1F12, encoding a protein similar to diubiquitin. The 1.1-kb transcript was detected only in B-cell lines transformed by Epstein-Barr virus.

By subtractive hybridization of dendritic cell (DC) libraries and EST database searching, Bates et al. (1997) obtained a full-length cDNA encoding diubiquitin. The predicted 165-amino acid protein has 2 ubiquitin-like domains, each of which has 2 cysteines. Southern blot analysis indicated that the cDNA represents a single-copy gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB744Hu01 Recombinant Ubiquitin D (UBD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB744Hu01 Polyclonal Antibody to Ubiquitin D (UBD) WB; IHC; ICC; IP.
MAB744Hu22 Monoclonal Antibody to Ubiquitin D (UBD) WB; IHC; ICC; IP.
Assay Kits SEB744Hu ELISA Kit for Ubiquitin D (UBD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB744Mu01 Recombinant Ubiquitin D (UBD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ubiquitin D (UBD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin D (UBD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin D (UBD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin D (UBD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB744Ra01 Recombinant Ubiquitin D (UBD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB744Ra01 Polyclonal Antibody to Ubiquitin D (UBD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitin D (UBD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin D (UBD) ELISA Kit Customized Service Offer
  1. "Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells."Eur. J. Immunol. 27:2471-2477(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2."Proc. Natl. Acad. Sci. U.S.A. 96:4313-4318(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers."Oncogene 22:2592-2603(2003) [PubMed] [Europe PMC] [Abstract]
  6. "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation."J. Biol. Chem. 279:16503-16510(2004) [PubMed] [Europe PMC] [Abstract]
  7. "FAT10, a ubiquitin-independent signal for proteasomal degradation."Mol. Cell. Biol. 25:3483-3491(2005) [PubMed] [Europe PMC] [Abstract]
  8. "FAT10, a gene up-regulated in various cancers, is cell-cycle regulated."Cell Div. 1:20-20(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease."J. Am. Soc. Nephrol. 17:996-1004(2006) [PubMed] [Europe PMC] [Abstract]
  10. "FAT10 plays a role in the regulation of chromosomal stability."J. Biol. Chem. 281:11413-11421(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10."J. Biol. Chem. 281:20045-20054(2006) [PubMed] [Europe PMC] [Abstract]
  12. "p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers."Oncogene 25:2318-2327(2006) [PubMed] [Europe PMC] [Abstract]
  13. "E1-L2 activates both ubiquitin and FAT10."Mol. Cell 27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract]
  14. "The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition."J. Cell Sci. 121:4079-4088(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon."Oncogene 27:6068-6074(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L."FEBS Lett. 583:591-594(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system."Int. J. Biochem. Cell Biol. 41:1205-1215(2009) [PubMed] [Europe PMC] [Abstract]
  18. "FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy."J. Virol. 83:11983-11988(2009) [PubMed] [Europe PMC] [Abstract]
  19. "FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging."World J. Gastroenterol. 15:2228-2233(2009) [PubMed] [Europe PMC] [Abstract]
  20. "The ubiquitin-like protein FAT10 mediates NF-kappa-B activation."J. Am. Soc. Nephrol. 21:316-326(2010) [PubMed] [Europe PMC] [Abstract]