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Tryptophanyl tRNA Synthetase (WARS)

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GAMMA-2; IFI53; IFP53; WRS; TrpRS; hWRS; Tryptophan tRNA Ligase 1,Cytoplasmic; Interferon-induced protein 53; Tryptophanyl-tRNA synthetase

Tryptophanyl tRNA Synthetase (WARS)
CCC B748
HGNC 12729
MGI 104630
PubMed 16798914
RGD 1308278
UniProt P23381
Wiki WARS_(gene

Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene,Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.

Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB748Hu01 Recombinant Tryptophanyl tRNA Synthetase (WARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB748Hu01 Polyclonal Antibody to Tryptophanyl tRNA Synthetase (WARS) WB; IHC; ICC; IP.
Assay Kits SEB748Hu ELISA Kit for Tryptophanyl tRNA Synthetase (WARS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB748Mu01 Recombinant Tryptophanyl tRNA Synthetase (WARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB748Mu01 Polyclonal Antibody to Tryptophanyl tRNA Synthetase (WARS) WB; IHC; ICC; IP.
Assay Kits SEB748Mu ELISA Kit for Tryptophanyl tRNA Synthetase (WARS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB748Ra01 Recombinant Tryptophanyl tRNA Synthetase (WARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB748Ra01 Polyclonal Antibody to Tryptophanyl tRNA Synthetase (WARS) WB; IHC; ICC; IP.
Assay Kits SEB748Ra ELISA Kit for Tryptophanyl tRNA Synthetase (WARS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts."J. Biol. Chem. 266:24245-24248(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase."Proc. Natl. Acad. Sci. U.S.A. 88:11520-11524(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and nucleotide sequence of the structural gene encoding for human tryptophanyl-tRNA synthetase."Gene 109:291-296(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor."EMBO J. 11:489-496(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Alternative splicing of 5'-terminal exons of the human tryptophanyl-tRNA synthetase gene."Mol. Biol. (Mosk.) 30:319-329(1996) [PubMed] [Europe PMC] [Abstract]
  9. "The human gene encoding tryptophanyl-tRNA synthetase: interferon-response elements and exon-intron organization."Gene 128:237-245(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Gamma interferon potently induces tryptophanyl-tRNA synthetase expression in human keratinocytes."J. Invest. Dermatol. 100:775-779(1993) [PubMed] [Europe PMC] [Abstract]