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EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2)

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CD312; EGF-like module receptor 2

EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2)
CCC B754
HGNC 3337
PubMed 17174274
UniProt Q9UHX3
Wiki EMR2

EGF-like module-containing mucin-like hormone receptor-like 2 is a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19.

This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB754Hu01 Recombinant EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB754Hu01 Polyclonal Antibody to EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) ELISA Kit Customized Service Offer
  1. "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97."Genomics 67:188-200(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif."FEBS Lett. 547:145-150(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells."J. Leukoc. Biol. 71:854-862(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans."Blood 102:2916-2924(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif."J. Biol. Chem. 279:31823-31832(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function."FASEB J. 22:741-751(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains."Mol. Cell. Biol. 32:1408-1420(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55."J. Biol. Chem. 282:22023-22032(2007) [PubMed] [Europe PMC] [Abstract]