Rho Family GTPase 1 (RND1)

Rnd1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).By screening a human fetal brain cDNA library using bovine Rnd1 as probe, Nobes et al. (1998) cloned RND1.

The deduced protein contains 232 amino acids and has a calculated molecular mass of 26 kD. It contains 3 guanine-binding motifs, 2 loops and a threonine involved in phosphate binding, and 3 major residues that coordinate magnesium in the GTP-bound state. However, RND1 lacks the residues important for the intrinsic GTPase activity of RAS .