≡

Fibroblast Growth Factor Receptor 2 (FGFR2)

[Edit]

CD332; BEK; BFR1; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; Bacteria-Expressed Kinase,Keratinocyte Growth Factor Receptor; Craniofacial Dysostosis 1; Crouzon Syndrome

Fibroblast Growth Factor Receptor 2 (FGFR2)
CCC B794
HGNC 3689
MGI 95523
PubMed 9435295
RGD 2611
UniProt P21802
Wiki FGFR2

Fibroblast growth factor receptor 2 (FGFR2) is a receptor for fibroblast growth factor encoded on a gene residing on chromosome 10. FGFR2 has also been designated as CD332 (cluster of differentiation 332). The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution.

FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB794Hu01 Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB794Hu01 Polyclonal Antibody to Fibroblast Growth Factor Receptor 2 (FGFR2) WB; IHC; ICC; IP.
MAB794Hu22 Monoclonal Antibody to Fibroblast Growth Factor Receptor 2 (FGFR2) WB; IHC; ICC; IP.
Assay Kits SEB794Hu ELISA Kit for Fibroblast Growth Factor Receptor 2 (FGFR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor Receptor 2 (FGFR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor Receptor 2 (FGFR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Receptor 2 (FGFR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Receptor 2 (FGFR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB794Ra01 Recombinant Fibroblast Growth Factor Receptor 2 (FGFR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB794Ra01 Polyclonal Antibody to Fibroblast Growth Factor Receptor 2 (FGFR2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Receptor 2 (FGFR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Receptor 2 (FGFR2) ELISA Kit Customized Service Offer
  1. "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors."EMBO J. 9:2685-2692(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Related fibroblast growth factor receptor genes exist in the human genome."Proc. Natl. Acad. Sci. U.S.A. 87:8180-8184(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Two cDNAs encoding novel human FGF receptor."Biochim. Biophys. Acta 1089:244-246(1991) [PubMed] [Europe PMC] [Abstract]
  4. "K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes."Proc. Natl. Acad. Sci. U.S.A. 87:5983-5987(1990) [PubMed] [Europe PMC] [Abstract]
  5. "K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase."Proc. Natl. Acad. Sci. U.S.A. 89:2960-2964(1992) [PubMed] [Europe PMC] [Abstract]
  6. "A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity."J. Biol. Chem. 267:21225-21229(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene."Proc. Natl. Acad. Sci. U.S.A. 89:246-250(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and their receptors in human breast cells and tissues: alternative receptors."Cell. Mol. Biol. Res. 40:337-350(1994) [PubMed] [Europe PMC] [Abstract]
  9. ErratumCell. Mol. Biol. Res. 40:707-707(1994)
  10. "Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs."Cancer Res. 59:6080-6086(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Fibroblast growth factor receptor 2 (FGFR2): genomic sequence and variations."Cytogenet. Cell Genet. 94:121-126(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome."Am. J. Hum. Genet. 66:768-777(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Genomic organization of the human fibroblast growth factor receptor 2 (FGFR2) gene and comparative analysis of the human FGFR gene family."Gene 230:69-79(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Analysis of phenotypic features and FGFR2 mutations in Apert syndrome."Am. J. Hum. Genet. 57:321-328(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome."Rinsho Byori 44:435-438(1996) [PubMed] [Europe PMC] [Abstract]
  19. "Exclusive paternal origin of new mutations in Apert syndrome."Nat. Genet. 13:48-53(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Crouzon syndrome: mutations in two spliceoforms of FGFR2 and a common point mutation shared with Jackson-Weiss syndrome."Hum. Mol. Genet. 4:1387-1390(1995) [PubMed] [Europe PMC] [Abstract]
  21. "Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor."Biochemistry 35:15640-15645(1996) [PubMed] [Europe PMC] [Abstract]
  22. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  23. "p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death."J. Biol. Chem. 278:10374-10380(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation."J. Biol. Chem. 279:36259-36267(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis."Biochem. Biophys. Res. Commun. 327:523-532(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F."J. Biol. Chem. 281:27292-27305(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."J. Biol. Chem. 282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]
  29. "Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus."J. Cell. Physiol. 212:148-156(2007) [PubMed] [Europe PMC] [Abstract]
  30. "FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival."Bone 42:1032-1039(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Novel phosphotyrosine targets of FGFR2IIIb signaling."Cell. Signal. 21:1370-1378(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform."J. Biol. Chem. 284:6227-6240(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  34. "The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination."J. Biol. Chem. 286:24443-24450(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Cellular signaling by fibroblast growth factor receptors."Cytokine Growth Factor Rev. 16:139-149(2005) [PubMed] [Europe PMC] [Abstract]
  36. "FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies."J. Invest. Dermatol. 129:1861-1867(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  38. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  39. "Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity."Cell 101:413-424(2000) [PubMed] [Europe PMC] [Abstract]
  40. "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin."Nature 407:1029-1034(2000) [PubMed] [Europe PMC] [Abstract]
  41. "Structural interactions of fibroblast growth factor receptor with its ligands."Proc. Natl. Acad. Sci. U.S.A. 97:49-54(2000) [PubMed] [Europe PMC] [Abstract]
  42. "Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome."Proc. Natl. Acad. Sci. U.S.A. 98:7182-7187(2001) [PubMed] [Europe PMC] [Abstract]
  43. "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors."Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003) [PubMed] [Europe PMC] [Abstract]
  44. "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."Genes Dev. 20:185-198(2006) [PubMed] [Europe PMC] [Abstract]
  45. "A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases."Mol. Cell 27:717-730(2007) [PubMed] [Europe PMC] [Abstract]
  46. "Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation."Proc. Natl. Acad. Sci. U.S.A. 104:19802-19807(2007) [PubMed] [Europe PMC] [Abstract]
  47. "A crystallographic snapshot of tyrosine trans-phosphorylation in action."Proc. Natl. Acad. Sci. U.S.A. 105:19660-19665(2008) [PubMed] [Europe PMC] [Abstract]
  48. "A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor."J. Biol. Chem. 286:20677-20687(2011) [PubMed] [Europe PMC] [Abstract]
  49. "Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome."Nat. Genet. 8:98-103(1994) [PubMed] [Europe PMC] [Abstract]
  50. "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2."Nat. Genet. 8:275-279(1994) [PubMed] [Europe PMC] [Abstract]
  51. "Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome."Hum. Mol. Genet. 4:1077-1082(1995) [PubMed] [Europe PMC] [Abstract]
  52. "Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability."Hum. Mol. Genet. 4:1229-1233(1995) [PubMed] [Europe PMC] [Abstract]
  53. "FGFR2 mutations in Pfeiffer syndrome."Nat. Genet. 9:108-108(1995) [PubMed] [Europe PMC] [Abstract]
  54. "Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome."Nat. Genet. 9:165-172(1995) [PubMed] [Europe PMC] [Abstract]
  55. "Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes."Nat. Genet. 9:173-176(1995) [PubMed] [Europe PMC] [Abstract]
  56. "FGFR2 exon IIIa and IIIc mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes: evidence for missense changes, insertions, and a deletion due to alternative RNA splicing."Am. J. Hum. Genet. 58:491-498(1996) [PubMed] [Europe PMC] [Abstract]
  57. "Spectrum of craniosynostosis phenotypes associated with novel mutations at the fibroblast growth factor receptor 2 locus."Eur. J. Hum. Genet. 4:283-291(1996) [PubMed] [Europe PMC] [Abstract]
  58. "Crouzon syndrome: previously unrecognized deletion, duplication, and point mutation within FGFR2 gene."Hum. Mutat. 8:386-390(1996) [PubMed] [Europe PMC] [Abstract]
  59. "Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome."Nat. Genet. 13:492-494(1996) [PubMed] [Europe PMC] [Abstract]
  60. "Trp290Cys mutation in exon IIIa of the fibroblast growth factor receptor 2 (FGFR2) gene is associated with Pfeiffer syndrome."Hum. Genet. 99:602-606(1997) [PubMed] [Europe PMC] [Abstract]
  61. "Jackson-Weiss syndrome: identification of two novel FGFR2 missense mutations shared with Crouzon and Pfeiffer craniosynostotic disorders."Hum. Genet. 101:47-50(1997) [PubMed] [Europe PMC] [Abstract]
  62. "Genotype-phenotype correlation for nucleotide substitutions in the IgII-IgIII linker of FGFR2."Hum. Mol. Genet. 6:137-143(1997) [PubMed] [Europe PMC] [Abstract]
  63. "A novel mutation (a886g) in exon 5 of FGFR2 in members of a family with Crouzon phenotype and plagiocephaly."J. Med. Genet. 34:420-422(1997) [PubMed] [Europe PMC] [Abstract]
  64. "Description of a new mutation and characterization of FGFR1, FGFR2, and FGFR3 mutations among Brazilian patients with syndromic craniosynostoses."Am. J. Med. Genet. 78:237-241(1998) [PubMed] [Europe PMC] [Abstract]
  65. "The mutations in FGFR2-associated craniosynostoses are clustered in five structural elements of immunoglobulin-like domain III of the receptor."Hum. Genet. 102:145-150(1998) [PubMed] [Europe PMC] [Abstract]
  66. "Two common mutations 934C to G and 937C to G of fibroblast growth factor receptor 2 (FGFR2) gene in Chinese patients with Apert syndrome."Hum. Mutat. Suppl. 1:S18-S19(1998) [PubMed] [Europe PMC] [Abstract]
  67. "Pfeiffer's syndrome resulting from an S351C mutation in the fibroblast growth factor receptor-2 gene."J. Craniofac. Surg. 9:207-209(1998) [PubMed] [Europe PMC] [Abstract]
  68. "Presence of the Apert canonical S252W FGFR2 mutation in a patient without severe syndactyly."J. Med. Genet. 35:677-679(1998) [PubMed] [Europe PMC] [Abstract]
  69. "A novel FGFR2 gene mutation in Crouzon syndrome associated with apparent nonpenetrance."Cleft Palate Craniofac. J. 36:533-541(1999) [PubMed] [Europe PMC] [Abstract]
  70. "Analysis of the mutational spectrum of the FGFR2 gene in Pfeiffer syndrome."Hum. Genet. 104:425-431(1999) [PubMed] [Europe PMC] [Abstract]
  71. "Pfeiffer syndrome type 2 associated with a single amino acid deletion in the FGFR2 gene."Clin. Genet. 58:81-83(2000) [PubMed] [Europe PMC] [Abstract]
  72. "Clustering of FGFR2 gene mutations in patients with Pfeiffer and Crouzon syndromes (FGFR2-associated craniosynostoses)."Cytogenet. Cell Genet. 91:134-137(2000) [PubMed] [Europe PMC] [Abstract]
  73. "A novel mutation, Ala315Ser, in FGFR2: a gene-environment interaction leading to craniosynostosis?"Eur. J. Hum. Genet. 8:571-577(2000) [PubMed] [Europe PMC] [Abstract]
  74. "Evidence for digenic inheritance in some cases of Antley-Bixler syndrome?"J. Med. Genet. 37:26-32(2000) [PubMed] [Europe PMC] [Abstract]
  75. "Mutation analysis of Crouzon syndrome and identification of one novel mutation in Taiwanese patients."Pediatr. Int. 43:263-266(2001) [PubMed] [Europe PMC] [Abstract]
  76. "Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis."Am. J. Hum. Genet. 70:472-486(2002) [PubMed] [Europe PMC] [Abstract]
  77. "Mutation in the FGFR2 gene in a Taiwanese patient with Beare-Stevenson cutis gyrata syndrome."Clin. Genet. 61:218-221(2002) [PubMed] [Europe PMC] [Abstract]
  78. "Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain."J. Med. Genet. 42:656-662(2005) [PubMed] [Europe PMC] [Abstract]
  79. "Mutations in different components of FGF signaling in LADD syndrome." Nat. Genet. 38:414-417(2006) [PubMed] [Europe PMC] [Abstract]
  80. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  81. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  82. "Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling."Am. J. Hum. Genet. 90:550-557(2012) [PubMed] [Europe PMC] [Abstract]