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Natural Cytotoxicity Triggering Receptor 3 (NCR3)

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CD337; 1C7; LY117; NKp30; Lymphocyte Antigen 117; Activating natural killer receptor p30; Natural killer cell p30-related protein

Natural Cytotoxicity Triggering Receptor 3 (NCR3)
CCC B804
HGNC 19077
MGI 2149332
PubMed 23884468
UniProt O14931
Wiki NCR3

Natural cytotoxicity receptors (NCRs), such as NCR3, are activating natural killer (NK) cell receptors that belong to the immunoglobulin (Ig) superfamily. NCR3 is expressed in all resting and activated NK cells and forms a complex with CD3-zeta (CD3Z, or CD247)

The deduced 190-amino acid protein has a signal peptide followed by a 120-amino acid extracellular region that forms a V-type Ig-like domain with 2 potential N-linked glycosylation sites; a hydrophobic transmembrane region with a positively charged arg residue; and a 33-amino acid cytoplasmic tail lacking an immunoreceptor tyrosine-based activating motif (ITAM). Northern blot analysis detected a 1.0-kb transcript only in NK cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB804Hu01 Recombinant Natural Cytotoxicity Triggering Receptor 3 (NCR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB804Hu01 Polyclonal Antibody to Natural Cytotoxicity Triggering Receptor 3 (NCR3) WB; IHC; ICC; IP.
MAB804Hu21 Monoclonal Antibody to Natural Cytotoxicity Triggering Receptor 3 (NCR3) WB; IHC; ICC; IP.
Assay Kits SEB804Hu ELISA Kit for Natural Cytotoxicity Triggering Receptor 3 (NCR3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Natural Cytotoxicity Triggering Receptor 3 (NCR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Natural Cytotoxicity Triggering Receptor 3 (NCR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Natural Cytotoxicity Triggering Receptor 3 (NCR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Natural Cytotoxicity Triggering Receptor 3 (NCR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Natural Cytotoxicity Triggering Receptor 3 (NCR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB804Ra01 Recombinant Natural Cytotoxicity Triggering Receptor 3 (NCR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB804Ra01 Polyclonal Antibody to Natural Cytotoxicity Triggering Receptor 3 (NCR3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Natural Cytotoxicity Triggering Receptor 3 (NCR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Natural Cytotoxicity Triggering Receptor 3 (NCR3) ELISA Kit Customized Service Offer
  1. "Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells."J. Exp. Med. 190:1505-1516(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Genes in a 220-kb region spanning the TNF cluster in human MHC."Genomics 31:215-222(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor."Blood 106:566-571(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells."Immunity 27:965-974(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Association analyses of NCR3 polymorphisms with P. falciparum mild malaria."Microbes Infect. 9:160-166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function."PLoS ONE 3:E3377-E3377(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans."J. Exp. Med. 206:1495-1503(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6."J. Exp. Med. 208:703-714(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site."Proc. Natl. Acad. Sci. U.S.A. 108:6223-6228(2011) [PubMed] [Europe PMC] [Abstract]