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Jagged 1 (JAG1)

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CD339; AGS; AHD; AWS; HJ1; JAGL1; Alagille Syndrome; Jagged 1 Protein

Jagged 1 (JAG1)
CCC B807
HGNC 6188
MGI 1095416
PubMed 20437614
RGD 2937
UniProt P78504
Wiki JAG1

Jagged-1 is a ligand of the Notch receptor, and their binding triggers a cascade of proteolytic cleavage that eventually leads to the release of the intracellular part of the receptor from the membrane, allowing it to translocate to the nucleus and activate transcription factors that play key roles in cell differentiation and morphogenesis
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB807Hu01 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB807Hu02 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB807Hu03 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB807Hu04 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB807Hu01 Polyclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC; IP.
MAB807Hu22 Monoclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC; IP.
PAB807Hu02 Polyclonal Antibody to Jagged 1 (JAG1) WB
PAB807Hu03 Polyclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC; IP.
LAB807Hu71 Biotin-Linked Polyclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC.
LAB807Hu73 Biotin-Linked Polyclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC.
MAB807Hu21 Monoclonal Antibody to Jagged 1 (JAG1) WB
Assay Kits SEB807Hu ELISA Kit for Jagged 1 (JAG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB807Mu01 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB807Mu02 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB807Mu01 Polyclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC; IP.
PAB807Mu02 Polyclonal Antibody to Jagged 1 (JAG1) WB; IHC; ICC; IP.
Assay Kits SEB807Mu ELISA Kit for Jagged 1 (JAG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB807Ra01 Recombinant Jagged 1 (JAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Jagged 1 (JAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jagged 1 (JAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jagged 1 (JAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jagged 1 (JAG1) ELISA Kit Customized Service Offer
  1. "Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12."Genomics 43:376-379(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1."Nat. Genet. 16:243-251(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1."Immunity 8:43-55(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors."EMBO J. 18:2803-2811(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Human ligands of the Notch receptor."Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro."J. Biol. Chem. 271:32499-32502(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in the human Jagged1 gene are responsible for Alagille syndrome."Nat. Genet. 16:235-242(1997) [PubMed] [Europe PMC] [Abstract]
  11. "JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype."J. Med. Genet. 37:658-662(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition."Nat. Struct. Mol. Biol. 15:849-857(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Exon 6 of human JAG1 encodes a conserved structural unit."BMC Struct. Biol. 9:43-43(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Spectrum and frequency of Jagged1 (JAG1) mutations in Alagille syndrome patients and their families."Am. J. Hum. Genet. 62:1361-1369(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome."Gastroenterology 116:1141-1148(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Jagged-1 mutation analysis in Italian Alagille syndrome patients."Hum. Mutat. 14:394-400(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population."Hum. Mutat. 16:408-416(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Familial tetralogy of Fallot caused by mutation in the Jagged1 gene."Hum. Mol. Genet. 10:163-169(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome."Hum. Mol. Genet. 10:405-413(2001) [PubMed] [Europe PMC] [Abstract]
  21. "Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome."Hum. Mutat. 17:72-73(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients."Hum. Mutat. 17:151-152(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of Jagged 1."Am. J. Hum. Genet. 71:180-186(2002) [PubMed] [Europe PMC] [Abstract]
  24. "The significance of human Jagged 1 mutations detected in severe cases of extrahepatic biliary atresia."Hepatology 36:904-912(2002) [PubMed] [Europe PMC] [Abstract]
  25. "DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian Alagille syndrome patients."Hum. Mutat. 20:481-481(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage."Am. J. Hum. Genet. 72:1065-1070(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome."Hum. Mutat. 21:100-100(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Twelve novel JAG1 gene mutations in Polish Alagille syndrome patients."Hum. Mutat. 25:321-321(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate."Hum. Mutat. 27:436-443(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Alagille Syndrome: A new missense mutation detected by whole-exome sequencing in a case previously found to be negative by DHPLC and MLPA."Mol. Syndromol. 4:207-210(2013) [PubMed] [Europe PMC] [Abstract]