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Uridine Phosphorylase 1 (UPP1)

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UDRPASE; UP; UPASE

Uridine Phosphorylase 1 (UPP1)
CCC B811
HGNC 12576
MGI 1097668
PubMed 15714138
RGD 1305566
UniProt Q16831
Wiki UPP1

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate.

The recombinant UP expressed in COS-7 cells demonstrated specific enzyme activity with uridine as the substrate; this activity was inhibited by a competitive inhibitor. Northern blot analysis with the cDNA as a probe demonstrated high levels of mRNA expression in several tumor cell lines but a very low level in a normal cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB811Hu01 Recombinant Uridine Phosphorylase 1 (UPP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB811Hu01 Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Uridine Phosphorylase 1 (UPP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uridine Phosphorylase 1 (UPP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB811Mu01 Recombinant Uridine Phosphorylase 1 (UPP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB811Mu01 Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1) WB; IHC; ICC; IP.
Assay Kits SEB811Mu ELISA Kit for Uridine Phosphorylase 1 (UPP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Uridine Phosphorylase 1 (UPP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Uridine Phosphorylase 1 (UPP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uridine Phosphorylase 1 (UPP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uridine Phosphorylase 1 (UPP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uridine Phosphorylase 1 (UPP1) ELISA Kit Customized Service Offer
  1. "Cloning and expression of human uridine phosphorylase."Biochem. Biophys. Res. Commun. 216:265-272(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  4. "Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy."BMC Struct. Biol. 9:14-14(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Active site conformational dynamics in human uridine phosphorylase 1."PLoS ONE 5:E12741-E12741(2010) [PubMed] [Europe PMC] [Abstract]