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Frizzled Homolog 4 (FZD4)

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CD344; EVR1; FEVR; FZD4S; Fz-4; FzE4; GPCR; Exudative Vitreoretinopathy 1

Frizzled Homolog 4 (FZD4)
CCC B813
HGNC 4042
MGI 108520
PubMed 15223780
RGD 71017
UniProt Q9ULV1
Wiki FZD4

Frizzled homolog 4 (Drosophila), also known as FZD4, is a human gene. FZD4 has also been designated as CD344 . This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway.

This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB813Hu01 Recombinant Frizzled Homolog 4 (FZD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB813Hu01 Polyclonal Antibody to Frizzled Homolog 4 (FZD4) WB; IHC
Assay Kits n/a CLIA Kit for Frizzled Homolog 4 (FZD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Frizzled Homolog 4 (FZD4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Frizzled Homolog 4 (FZD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Frizzled Homolog 4 (FZD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Frizzled Homolog 4 (FZD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Frizzled Homolog 4 (FZD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Frizzled Homolog 4 (FZD4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Frizzled Homolog 4 (FZD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Frizzled Homolog 4 (FZD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Frizzled Homolog 4 (FZD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Frizzled Homolog 4 (FZD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Frizzled Homolog 4 (FZD4) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Frizzled Homolog 4 (FZD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Frizzled Homolog 4 (FZD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Frizzled Homolog 4 (FZD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Frizzled Homolog 4 (FZD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Frizzled Homolog 4 (FZD4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of human frizzled-4 on chromosome 11q14-q21."Biochem. Biophys. Res. Commun. 264:955-961(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
  6. "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy."Nat. Genet. 32:326-330(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity."Br. J. Ophthalmol. 87:1291-1295(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy."Am. J. Ophthalmol. 138:670-671(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair."Cell 116:883-895(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy."Invest. Ophthalmol. Vis. Sci. 45:2083-2090(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)."Ophthalmic Genet. 25:81-90(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic variants of frizzled-4 gene in familial exudative vitreoretinopathy and advanced retinopathy of prematurity."Clin. Genet. 67:363-366(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes."Hum. Mutat. 26:104-112(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy."Mol. Vis. 12:1086-1092(2006) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy."Hum. Genet. 122:615-623(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Clinical and molecular evaluation of probands and family members with familial exudative vitreoretinopathy."Invest. Ophthalmol. Vis. Sci. 50:4379-4385(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Phenotypic overlap of familial exudative vitreoretinopathy (FEVR) with persistent fetal vasculature (PFV) caused by FZD4 mutations in two distinct pedigrees."Ophthalmic Genet. 30:23-30(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP."Hum. Mutat. 31:656-666(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Severe retinopathy of prematurity associated with FZD4 mutations."Ophthalmic Genet. 31:37-43(2010) [PubMed] [Europe PMC] [Abstract]