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Inhibitory Subunit Of NF Kappa B Beta (IkBb)

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TRIP9; NFKBIB; Thyroid receptor-interacting protein 9; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor,Beta; NF-Kappa-B Inhibitor Beta

Inhibitory Subunit Of NF Kappa B Beta (IkBb)
CCC B849
HGNC 7798
MGI 104752
PubMed 9763672
RGD 621887
UniProt Q15653
Wiki NFKBIB

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.

Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB849Hu01 Recombinant Inhibitory Subunit Of NF Kappa B Beta (IkBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB849Hu01 Polyclonal Antibody to Inhibitory Subunit Of NF Kappa B Beta (IkBb) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Inhibitory Subunit Of NF Kappa B Beta (IkBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitory Subunit Of NF Kappa B Beta (IkBb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB849Mu01 Recombinant Inhibitory Subunit Of NF Kappa B Beta (IkBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB849Mu01 Polyclonal Antibody to Inhibitory Subunit Of NF Kappa B Beta (IkBb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Inhibitory Subunit Of NF Kappa B Beta (IkBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitory Subunit Of NF Kappa B Beta (IkBb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitory Subunit Of NF Kappa B Beta (IkBb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitory Subunit Of NF Kappa B Beta (IkBb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitory Subunit Of NF Kappa B Beta (IkBb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitory Subunit Of NF Kappa B Beta (IkBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitory Subunit Of NF Kappa B Beta (IkBb) ELISA Kit Customized Service Offer
  1. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Role of unphosphorylated, newly synthesized IkappaB beta in persistent activation of NF-kappaB."Mol. Cell. Biol. 16:5444-5449(1996) [PubMed] [Europe PMC] [Abstract]
  5. "A subclass of Ras proteins that regulate the degradation of IkappaB."Science 287:869-873(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation."Mol. Cell. Biol. 16:1295-1304(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product."Mol. Cell. Biol. 16:5974-5984(1996) [PubMed] [Europe PMC] [Abstract]
  8. "KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes."J. Biol. Chem. 278:23101-23106(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras."Mol. Cell. Biol. 24:3048-3056(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of COMMD protein-protein interactions in NF-kappaB signalling."Biochem. J. 398:63-71(2006) [PubMed] [Europe PMC] [Abstract]
  11. "DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha stability."PLoS ONE 8:E64231-E64231(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]