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Coagulation Factor VII (F7)

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FVII; SPCA; proconvertin; Cothromboplastin; Serum Prothrombin Conversation Accelerator; Stable Factor; Eptacog alfa

Coagulation Factor VII (F7)
CCC B874
HGNC 3544
MGI 109325
PubMed 17159685
RGD 628678
UniProt P08709
Wiki Factor_VII

The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself.

The most important substrates for FVIIa-TF are Factor X and Factor IX. The action of the factor is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent; it is produced in the liver. Use of warfarin or similar anticoagulants impairs its function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB874Hu01 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB874Hu01 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
MAB874Hu22 Monoclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
LAB874Hu71 Biotin-Linked Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC.
Assay Kits SEB874Hu ELISA Kit for Coagulation Factor VII (F7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB874Mu01 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
RPB874Mu02 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB874Mu01 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
LAB874Mu71 Biotin-Linked Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC.
PAB874Mu02 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
Assay Kits SEB874Mu ELISA Kit for Coagulation Factor VII (F7) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB874Mu High Sensitive ELISA Kit for Coagulation Factor VII (F7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB874Ra01 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
RPB874Ra02 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
APB874Ra02 Active Coagulation Factor VII (F7) Cell culture; Activity Assays.
RPB874Ra03 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB874Ra01 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
PAB874Ra02 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
LAB874Ra71 Biotin-Linked Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC.
Assay Kits SEB874Ra ELISA Kit for Coagulation Factor VII (F7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB874Rb01 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB874Rb51 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
PAB874Rb01 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Coagulation Factor VII (F7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coagulation Factor VII (F7) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB874Bo01 Recombinant Coagulation Factor VII (F7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB874Bo01 Polyclonal Antibody to Coagulation Factor VII (F7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Coagulation Factor VII (F7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coagulation Factor VII (F7) ELISA Kit Customized Service Offer
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  21. "Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor."Blood 83:3524-3535(1994) [PubMed] [Europe PMC] [Abstract]
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  33. ErratumNat. Genet. 23:373-373(1999)
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  39. "A patient homozygous for a Gly354Cys mutation in factor VII that results in severely impaired secretion of the molecule, but not complete deficiency."Br. J. Haematol. 124:336-342(2004) [PubMed] [Europe PMC] [Abstract]
  40. "Phenotypic and genotypic characterization of Factor VII deficiency patients from Western India."Clin. Chim. Acta 409:106-111(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene."Haemophilia 15:267-280(2009) [PubMed] [Europe PMC] [Abstract]
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  43. "Recurrent mutations and genotype-phenotype correlations in hereditary factor VII deficiency in Korea."Blood Coagul. Fibrinolysis 22:102-105(2011) [PubMed] [Europe PMC] [Abstract]
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