≡

Forkhead Box P3 (FOXP3)

[Edit]

FOX-P3; AIID; DIETER; IPEX; JM2; PIDX; XPID; SCURFIN; Forkhead Box Protein P3; Immune Dysregulation,Polyendocrinopathy,Enteropathy,X-Linked

Forkhead Box P3 (FOXP3)
CCC B877
HGNC 6106
MGI 1891436
PubMed 18024188
RGD 1562112
UniProt Q9BZS1
Wiki FOXP3

Foxp3 is a member of the forkhead/winged-helix family of transcriptional regulators and functions as the master regulator in the development and function of regulatory T cells. Human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to chromosome Xp11.23.
Foxp3 gene is mutated in the X-linked syndrome of immunodysregulation, polyendocrinopathy, and enteropathy (IPEX). These mutations were in the forkhead domain of FOXP3, indicating that the mutations may disrupt critical DNA interactions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB877Hu01 Recombinant Forkhead Box P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB877Hu02 Recombinant Forkhead Box P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB877Hu01 Polyclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
MAB877Hu22 Monoclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
MAB877Hu21 Monoclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
Assay Kits SEB877Hu ELISA Kit for Forkhead Box P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB877Mu01 Recombinant Forkhead Box P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB877Mu02 Recombinant Forkhead Box P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB877Mu01 Polyclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
PAB877Mu02 Polyclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
MAB877Mu21 Monoclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
Assay Kits SEB877Mu ELISA Kit for Forkhead Box P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB877Ra01 Recombinant Forkhead Box P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB877Ra01 Polyclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
MAB877Ra21 Monoclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
Assay Kits SEB877Ra ELISA Kit for Forkhead Box P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box P3 (FOXP3) Recombinant Protein Customized Service Offer
Antibodies MAB877Bo22 Monoclonal Antibody to Forkhead Box P3 (FOXP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Forkhead Box P3 (FOXP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box P3 (FOXP3) ELISA Kit Customized Service Offer
  1. "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse."Nat. Genet. 27:68-73(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells."Proc. Natl. Acad. Sci. U.S.A. 102:5138-5143(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1."Nature 446:685-689(2007) [PubMed] [Europe PMC] [Abstract]
  6. "FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression."Proc. Natl. Acad. Sci. U.S.A. 104:4571-4576(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3."J. Immunol. 180:4785-4792(2008) [PubMed] [Europe PMC] [Abstract]
  8. "TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function."Nature 453:236-240(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Foxp3 processing by proprotein convertases and control of regulatory T cell function."J. Biol. Chem. 284:5709-5716(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells."Eur. J. Immunol. 42:1627-1638(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells."J. Immunol. 188:2712-2721(2012) [PubMed] [Europe PMC] [Abstract]
  13. "A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells."Blood 121:1265-1275(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Searching for the Achilles Heel of FOXP3."Front. Oncol. 3:294-294(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity."Immunity 39:259-271(2013) [PubMed] [Europe PMC] [Abstract]
  16. "The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3." Immunity 39:272-285(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28."J. Immunol. 190:4470-4473(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis."Nat. Med. 19:322-328(2013) [PubMed] [Europe PMC] [Abstract]
  19. "The role of FOXP3 in regulating immune responses."Int. Rev. Immunol. 33:110-128(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Forkhead box P3: the peacekeeper of the immune system."Int. Rev. Immunol. 33:129-145(2014) [PubMed] [Europe PMC] [Abstract]
  21. "FOXP3 and scurfy: how it all began."Nat. Rev. Immunol. 14:343-349(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Post-translational modification networks regulating FOXP3 function."Trends Immunol. 35:368-378(2014) [PubMed] [Europe PMC] [Abstract]
  23. "JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome."J. Clin. Invest. 106:R75-R81(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)."J. Med. Genet. 38:874-876(2001) [PubMed] [Europe PMC] [Abstract]
  25. "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy."Nat. Genet. 27:18-20(2001) [PubMed] [Europe PMC] [Abstract]
  26. "The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3."Nat. Genet. 27:20-21(2001) [PubMed] [Europe PMC] [Abstract]