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Cyclin Dependent Kinase 1 (CDK1)

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CDC2; CDC28A; CDK1; CDC28-A; CDKN1; P34CDC2; p34 protein kinase; Cell Division Control Protein 2 Homolog; Cell Division Cycle 2,G1 To S And G2 To M

Cyclin Dependent Kinase 1 (CDK1)
CCC B888
HGNC 1722
MGI 88351
PubMed 22355113
RGD 2319
UniProt P06493
Wiki Cdk1

Cell division cycle 2, G1 to S and G2 to M, a catalytic subunit of the highly conserved protein kinase complex known as maturation promoting factor (MPF), which is essential G2/M phase transitions of the mammalian cell cycle. In higher eukaryotes, eg mammals one should note the presence of cdk4,cdk6 and cdk2 as the active kinases in control of the G1/S checkpoint. Mitotic cyclins stably associate with this protein and function as regulatory subunits.

The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB888Hu01 Recombinant Cyclin Dependent Kinase 1 (CDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB888Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) WB; IHC; ICC; IP.
MAB888Hu22 Monoclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) WB; IHC; ICC; IP.
LAB888Hu71 Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) WB; IHC; ICC.
Assay Kits SEB888Hu ELISA Kit for Cyclin Dependent Kinase 1 (CDK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB888Mu01 Recombinant Cyclin Dependent Kinase 1 (CDK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB888Mu02 Recombinant Cyclin Dependent Kinase 1 (CDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB888Mu01 Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) WB; IHC; ICC; IP.
PAB888Mu02 Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) WB; IHC; ICC; IP.
LAB888Mu71 Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 1 (CDK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 1 (CDK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 1 (CDK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 1 (CDK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 1 (CDK1) ELISA Kit Customized Service Offer
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  23. "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome."J. Cell Sci. 122:2240-2251(2009) [PubMed] [Europe PMC] [Abstract]
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  28. "New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses."EMBO Rep. 11:393-399(2010) [PubMed] [Europe PMC] [Abstract]
  29. "The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint."J. Biol. Chem. 285:1879-1887(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition."J. Biol. Chem. 285:16978-16990(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis."Mol. Cell. Biol. 30:640-656(2010) [PubMed] [Europe PMC] [Abstract]
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  41. "Cdc2: a monopotent or pluripotent CDK?"Cell Prolif. 44:205-211(2011) [PubMed] [Europe PMC] [Abstract]
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