Interleukin 7 Receptor (IL7R)

Interleukin-7 receptor is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB905Hu01 Recombinant Interleukin 7 Receptor (IL7R) Positive Control; Immunogen; SDS-PAGE; WB.
EPB905Hu61 Eukaryotic Interleukin 7 Receptor (IL7R) Positive Control; Immunogen; SDS-PAGE; WB.
APB905Hu61 Active Interleukin 7 Receptor (IL7R) Cell culture; Activity Assays.
EPB905Hu62 Eukaryotic Interleukin 7 Receptor (IL7R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB905Hu01 Polyclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC
MAB905Hu22 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB.
MAB905Hu26 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
MAB905Hu21 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
MAB905Hu23 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
MAB905Hu24 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
MAB905Hu25 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
Assay Kits SEB905Hu ELISA Kit for Interleukin 7 Receptor (IL7R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB905Mu01 Recombinant Interleukin 7 Receptor (IL7R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB905Mu01 Polyclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
LAB905Mu71 Biotin-Linked Polyclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Interleukin 7 Receptor (IL7R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 7 Receptor (IL7R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB905Ra01 Recombinant Interleukin 7 Receptor (IL7R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB905Ra01 Polyclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
MAB905Ra21 Monoclonal Antibody to Interleukin 7 Receptor (IL7R) WB; IHC; ICC; IP.
Assay Kits SEB905Ra ELISA Kit for Interleukin 7 Receptor (IL7R) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter."Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency."Nat. Genet. 20:394-397(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and biophysical studies of the human IL-7/IL-7Ralpha complex."Structure 17:54-65(2009) [PubMed] [Europe PMC] [Abstract]
  8. "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency."Blood 96:2803-2807(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis."Nat. Genet. 39:1083-1091(2007) [PubMed] [Europe PMC] [Abstract]