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Interleukin 28 Receptor (IL28R)

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IL28RA; CRF2/12; IFNLR1; LICR2; Interferon,Lambda Receptor; Cytokine receptor class-II member 12; Interleukin-28 receptor subunit alpha; Likely interleukin or cytokine receptor 2

Interleukin 28 Receptor (IL28R)
CCC B906
HGNC 18584
MGI 2429859
PubMed 20649452
RGD 1562689
UniProt Q8IU57
Wiki IL28R

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29).

The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 28 Receptor (IL28R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 28 Receptor (IL28R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 28 Receptor (IL28R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 28 Receptor (IL28R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 28 Receptor (IL28R) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 28 Receptor (IL28R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 28 Receptor (IL28R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 28 Receptor (IL28R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 28 Receptor (IL28R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 28 Receptor (IL28R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 28 Receptor (IL28R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 28 Receptor (IL28R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 28 Receptor (IL28R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 28 Receptor (IL28R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 28 Receptor (IL28R) ELISA Kit Customized Service Offer
  1. "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3."Biochem. J. 370:391-396(2003) [PubMed] [Europe PMC] [Abstract]
  2. "IL-28, IL-29 and their class II cytokine receptor IL-28R." Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  3. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1."J. Mol. Biol. 404:650-664(2010) [PubMed] [Europe PMC] [Abstract]