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Fumarase (FUM)

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FH; Fumarate Hydratase, mitochondrial

Fumarase (FUM)
CCC B931
HGNC 3700
MGI 95530
PubMed 12021453
RGD 2614
UniProt P07954
Wiki Fumarase

Fumarase (or fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of Fumarate to S-malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Citric Acid Cycle), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular localization is established by the presence of a signal sequence on the amino terminus in the mitochondrial form, while subcellular localization in the cytosolic form is established by the abence of the signal sequence found in the mitochondrial variety. This enzyme participates in 3 metabolic pathways: citric acid cycle, reductive carboxylation cycle (CO2 fixation), and in renal cell carcinoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB931Hu01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB931Hu01 Polyclonal Antibody to Fumarase (FUM) WB,IHC,ICC/IF
Assay Kits n/a CLIA Kit for Fumarase (FUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fumarase (FUM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB931Mu01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB931Mu01 Polyclonal Antibody to Fumarase (FUM) WB,IHC
Assay Kits n/a CLIA Kit for Fumarase (FUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fumarase (FUM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fumarase (FUM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fumarase (FUM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fumarase (FUM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fumarase (FUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fumarase (FUM) ELISA Kit Customized Service Offer
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  4. , Submitted (MAR-2007) to UniProtKB
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  10. "Crystal structure of human fumarate hydratase."Submitted (DEC-2012) to the PDB data bank
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