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Syndecan 4 (SDC4)

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SYND4; Amphiglycan; Ryudocan; Ryudocan core protein

Syndecan 4 (SDC4)
CCC B939
HGNC 10661
MGI 1349164
PubMed 11544026
RGD 3650
UniProt P31431
Wiki SDC4

Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan4 is upregulated in osteoarthritis and inhibition of syndecan 4 reduces cartilage destruction in mouse models of OA.

Syndecans, including SDC4, can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparan sulfate chains. Flow cytometric analysis demonstrated SDC expression on endothelial cells. HIV bound to SDC on endothelial cell lines maintained its infectivity for at least 1 week, compared with less than 1 day for unbound virus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Hu01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
APB939Hu01 Active Syndecan 4 (SDC4) Cell culture; Activity Assays.
Antibodies PAB939Hu01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
MAB939Hu22 Monoclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
Assay Kits SEB939Hu ELISA Kit for Syndecan 4 (SDC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Mu01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB939Mu01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
LAB939Mu71 Biotin-Linked Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Syndecan 4 (SDC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syndecan 4 (SDC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Ra01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB939Ra01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
LAB939Ra71 Biotin-Linked Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC.
LAB939Ra81 FITC-Linked Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IF.
MAB939Ra21 Monoclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
Assay Kits SEB939Ra ELISA Kit for Syndecan 4 (SDC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB939Ga01 Recombinant Syndecan 4 (SDC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB939Ga01 Polyclonal Antibody to Syndecan 4 (SDC4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Syndecan 4 (SDC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syndecan 4 (SDC4) ELISA Kit Customized Service Offer
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  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the dimeric cytoplasmic domain of syndecan-4."Biochemistry 40:8471-8478(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."Structure 11:845-853(2003) [PubMed] [Europe PMC] [Abstract]
  15. "The binding of the PDZ tandem of syntenin to target proteins."Biochemistry 45:3674-3683(2006) [PubMed] [Europe PMC] [Abstract]