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Calcium Release Activated Calcium Modulator 1 (CRACM1)

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ORAI1; TMEM142A; ORAT1; Transmembrane Protein 142A

Calcium Release Activated Calcium Modulator 1 (CRACM1)
CCC B942
HGNC 25896
MGI 1925542
PubMed 16645049
RGD 1311873
UniProt Q96D31
Wiki TMEM142A
Calcium release-activated calcium channel protein 1 is a calcium selective ion channel. Orai1 channels play important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, orai2 and orai3.
Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers. Orai channels are activated upon the depletion of internal calcium stores, which is called the "store-operated" or the "capacitative" mechanism. They are molecular constituents of the "calcium release activated calcium currents" (ICRAC).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Release Activated Calcium Modulator 1 (CRACM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Release Activated Calcium Modulator 1 (CRACM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Release Activated Calcium Modulator 1 (CRACM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Release Activated Calcium Modulator 1 (CRACM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Release Activated Calcium Modulator 1 (CRACM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Release Activated Calcium Modulator 1 (CRACM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Release Activated Calcium Modulator 1 (CRACM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Release Activated Calcium Modulator 1 (CRACM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Release Activated Calcium Modulator 1 (CRACM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Release Activated Calcium Modulator 1 (CRACM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Release Activated Calcium Modulator 1 (CRACM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Release Activated Calcium Modulator 1 (CRACM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Release Activated Calcium Modulator 1 (CRACM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Release Activated Calcium Modulator 1 (CRACM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Release Activated Calcium Modulator 1 (CRACM1) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients."J. Exp. Med. 202:651-662(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Orai1 and STIM reconstitute store-operated calcium channel function."J. Biol. Chem. 281:20661-20665(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Amplification of CRAC current by STIM1 and CRACM1 (Orai1)."Nat. Cell Biol. 8:771-773(2006) [PubMed] [Europe PMC] [Abstract]
  7. "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry."Science 312:1220-1223(2006) [PubMed] [Europe PMC] [Abstract]
  8. "STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation."FASEB J. 22:752-761(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1."Cell 136:876-890(2009) [PubMed] [Europe PMC] [Abstract]
  11. "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Alternative translation initiation gives rise to two isoforms of orai1 with distinct plasma membrane mobilities."J. Cell Sci. 125:4354-4361(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."Proc. Natl. Acad. Sci. U.S.A. 109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]
  14. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis."Proc. Natl. Acad. Sci. U.S.A. 111:4197-4202(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode."J. Biol. Chem. 287:43030-43041(2012) [PubMed] [Europe PMC] [Abstract]
  18. "STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry."Nat. Commun. 4:2963-2963(2013) [PubMed] [Europe PMC] [Abstract]
  19. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]