≡

Annexin A2 (ANXA2)

[Edit]

ANX-A2; ANX2L4; CAL1H; LIP2; LPC2; LPC2D; P36; PAP-IV; Protein I; Chromobindin-8; Calpactin-1 heavy chain; Lipocortin II; Placental anticoagulant protein IV

Annexin A2 (ANXA2)
CCC B944
HGNC 537
MGI 88246
PubMed 23091277
RGD 621170
UniProt P07355
Wiki Annexin_A2

Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body. This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB944Hu01 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB944Hu02 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
APB944Hu01 Active Annexin A2 (ANXA2) Cell culture; Activity Assays.
RPB944Hu03 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB944Hu04 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB944Hu01 Polyclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
MAB944Hu22 Monoclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
LAB944Hu71 Biotin-Linked Polyclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC.
PAB944Hu02 Polyclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP; FCM
MAB944Hu21 Monoclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
Assay Kits SEB944Hu ELISA Kit for Annexin A2 (ANXA2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB944Hu CLIA Kit for Annexin A2 (ANXA2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB944Mu01 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB944Mu02 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
APB944Mu01 Active Annexin A2 (ANXA2) Cell culture; Activity Assays.
Antibodies PAB944Mu01 Polyclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
PAB944Mu02 Polyclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
Assay Kits SEB944Mu ELISA Kit for Annexin A2 (ANXA2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB944Ra01 Recombinant Annexin A2 (ANXA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB944Ra01 Polyclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
MAB944Ra21 Monoclonal Antibody to Annexin A2 (ANXA2) WB; IHC; ICC; IP.
Assay Kits SEB944Ra ELISA Kit for Annexin A2 (ANXA2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase."Cell 46:191-199(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication."Gene 95:243-251(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (FEB-2008) to UniProtKB
  7. "The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha."J. Biol. Chem. 266:5169-5176(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells."Biochemistry 33:1223-1228(1994) [PubMed] [Europe PMC] [Abstract]
  9. "An endothelial cell-surface form of annexin II binds human cytomegalovirus."Biochem. Biophys. Res. Commun. 198:983-989(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Annexin II is a major component of fusogenic endosomal vesicles."J. Cell Biol. 120:1357-1369(1993) [PubMed] [Europe PMC] [Abstract]
  11. "The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo."Mol. Cell. Biol. 6:2738-2744(1986) [PubMed] [Europe PMC] [Abstract]
  12. "An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface."J. Biol. Chem. 279:43411-43418(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."Biochem. Biophys. Res. Commun. 336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility."PLoS ONE 6:E23070-E23070(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein."J. Mol. Biol. 257:839-847(1996) [PubMed] [Europe PMC] [Abstract]