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Nuclear Receptor Interacting Protein 1 (NRIP1)

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RIP140; Nuclear Factor RIP140

Nuclear Receptor Interacting Protein 1 (NRIP1)
CCC B961
HGNC 8001
MGI 1315213
PubMed 18267075
RGD 1311850
UniProt P48552
Wiki NRIP1

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor.
Knockout mice that completely lack the RIP140 molecule are lean and stay lean, even on a rich diet. RIP140 is part of the chain by which tumors can cause cachexia.
A major role for RIP140 in adipose tissue is to block the expression of genes involved in energy dissipation and mitochondrial uncoupling, including uncoupling protein 1 and carnitine palmitoyltransferase 1b.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Interacting Protein 1 (NRIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Interacting Protein 1 (NRIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Interacting Protein 1 (NRIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Interacting Protein 1 (NRIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Interacting Protein 1 (NRIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Interacting Protein 1 (NRIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Interacting Protein 1 (NRIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Interacting Protein 1 (NRIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Interacting Protein 1 (NRIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Interacting Protein 1 (NRIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Interacting Protein 1 (NRIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Interacting Protein 1 (NRIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Interacting Protein 1 (NRIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Interacting Protein 1 (NRIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Interacting Protein 1 (NRIP1) ELISA Kit Customized Service Offer
  1. "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor."EMBO J. 14:3741-3751(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4."J. Biol. Chem. 273:10948-10957(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids."J. Biol. Chem. 274:18121-18127(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP."Mol. Cell. Biol. 21:6181-6188(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140."Mol. Endocrinol. 15:501-511(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action."Mol. Endocrinol. 15:1586-1598(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140."Mol. Cell. Biol. 23:4187-4198(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect."Mol. Endocrinol. 17:287-299(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140."J. Biol. Chem. 279:15645-15651(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation."Mol. Cell. Proteomics 5:2072-2082(2006) [PubMed] [Europe PMC] [Abstract]
  14. "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)."J. Biol. Rhythms 26:187-199(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation."J. Biol. Chem. 281:37773-37781(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Preliminary molecular genetic analysis of the receptor interacting protein 140 (RIP140) in women affected by endometriosis."J. Exp. Clin. Assist. Reprod. 2:11-11(2005) [PubMed] [Europe PMC] [Abstract]