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Complement Component 8g (C8g)

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Complement Component 8g (C8g)
CCC B970
HGNC 1354
MGI 88237
PubMed 8865989
RGD 1309074
UniProt P07360

The eighth component of complement (C8) consists of 3 nonidentical subunits arranged asymmetrically as a disulfide-linked alpha-gamma dimer and a noncovalently associated beta chain. Genetic studies of C8 polymorphisms established that alpha-gamma and beta are encoded at different loci. Implicit in this finding was the existence of 2 different genes and the likelihood that alpha-gamma is synthesized as a single-chain precursor.

The C8G belong to the lipocalin superfamily, a group of distantly related and similarly folded proteins that are able to carry small lipophilic molecules such as retinol, odorants, and steroids. The lipocalin superfamily has a very ancient origin since lipocalins are found in arthropods as well as in vertebrates.

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Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB970Hu01 Recombinant Complement Component 8g (C8g) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB970Hu01 Polyclonal Antibody to Complement Component 8g (C8g) WB; IHC
MAB970Hu22 Monoclonal Antibody to Complement Component 8g (C8g) WB; IHC; ICC; IP.
Assay Kits SEB970Hu ELISA Kit for Complement Component 8g (C8g) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB970Hu CLIA Kit for Complement Component 8g (C8g) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 8g (C8g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 8g (C8g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 8g (C8g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 8g (C8g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 8g (C8g) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 8g (C8g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 8g (C8g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 8g (C8g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 8g (C8g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 8g (C8g) ELISA Kit Customized Service Offer
  1. "The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes."Biochemistry 26:5229-5233(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern."Biochem. Biophys. Res. Commun. 149:750-754(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family."Biochemistry 33:5162-5166(1994) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The homology of complement factor C8 gamma chain and alpha-1-microglobulin."Biochem. Biophys. Res. Commun. 149:282-288(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family."Mol. Immunol. 28:123-131(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Human complement protein C8 gamma."Biochim. Biophys. Acta 1482:199-208(2000) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site."Biochemistry 41:7030-7037(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family."Biochim. Biophys. Acta 1774:637-644(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding."Mol. Immunol. 45:750-756(2008) [PubMed] [Europe PMC] [Abstract]