Hepcidin (Hepc)

[Edit]

HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor

Hepcidin (Hepc)

Hepcidin is a peptide hormone produced by the liver discovered in 2000, that appears to be the master regulator of iron homeostasis in humans and other mammals. In humans, HAMP is the gene that encodes for hepcidin.
Hepcidin preprohormone, prohormone and hormone size are 84, 60 and 25 amino acids respectively. 20 and 22 amino acid forms of Hepcidin also exist in the urine. The N terminal region is required for function, and deletion of 5 N-terminal peptides results in a loss of function. Hepcidin has a beta-sheet rich structure with 4 disulfide bonds. Hepcidin directly inhibits ferroportin, a protein that transports iron out of cells that store it. This prevents enterocytes of the intestines from secreting iron into the hepatic portal system, reducing iron absorption.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Hu01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
EPB979Hu61 Eukaryotic Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
CPB979Hu12 BSA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
CPB979Hu22 OVA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
CPB979Hu23 OVA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
CPB979Hu21 OVA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
APB979Hu61 Active Hepcidin (Hepc) Cell culture; Activity Assays.
Antibodies PAB979Hu01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
LAB979Hu71 Biotin-Linked Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC.
LAB979Hu81 FITC-Linked Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IF.
PAB979Hu06 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
MAB979Hu26 Monoclonal Antibody to Hepcidin (Hepc) WB
PAB979Hu07 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
PAB979Hu09 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
MAB979Hu22 Monoclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
MAB979Hu21 Monoclonal Antibody to Hepcidin (Hepc) IHC
PAB979Mi01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
PAB979Hu08 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
Assay Kits SCB979Hu CLIA Kit for Hepcidin (Hepc) Chemiluminescent immunoassay for Antigen Detection.
CEB979Hu ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB979Hu ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.
CCB979Hu CLIA Kit for Hepcidin (Hepc) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Mu01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
RPB979Mu02 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB979Mu01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
LAB979Mu71 Biotin-Linked Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC.
LAB979Mu81 FITC-Linked Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IF.
PAB979Mu02 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
Assay Kits CEB979Mu ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB979Mu ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB979Mu High Sensitive ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Ra01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB979Ra01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
MAB979Ra21 Monoclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
Assay Kits CEB979Ra ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB979Ra ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB979Ra High Sensitive ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Ca01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Hepcidin (Hepc) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepcidin (Hepc) Polyclonal Antibody Customized Service Offer
Assay Kits SEB979Ca ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Po01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB979Po01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
MAB979Po21 Monoclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
Assay Kits CEB979Po ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Bo01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
CPB979Bo11 BSA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
CPB979Bo21 OVA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
CPB979Bo22 OVA Conjugated Hepcidin (Hepc) Immunogen; SDS-PAGE; WB.
Antibodies PAB979Bo01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
MAB979Bo21 Monoclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
PAB979Bo08 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
PAB979Bo09 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
PAB979Mi01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
Assay Kits SEB979Bo ELISA Kit for Hepcidin (Hepc) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB979Ge01 Recombinant Hepcidin (Hepc) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB979Ge01 Polyclonal Antibody to Hepcidin (Hepc) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hepcidin (Hepc) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepcidin (Hepc) ELISA Kit Customized Service Offer
  1. "Hepcidin: a urinary antimicrobial peptide synthesized in the liver."J. Biol. Chem. 276:7806-7810(2001) [PubMed] [Europe PMC] [Abstract]
  2. "LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity."FEBS Lett. 480:147-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Chemical synthesis of beta-defensins and LEAP-1/hepcidin."J. Pept. Res. 59:241-248(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Hepcidin and iron homeostasis."Biochim. Biophys. Acta 1823:1434-1443(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis."J. Biol. Chem. 277:37597-37603(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Hepcidin revisited, disulfide connectivity, dynamics, and structure."J. Biol. Chem. 284:24155-24167(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload."Clin. Chem. 49:1981-1988(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis."Hum. Mol. Genet. 12:2241-2247(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R)."Blood 103:2407-2409(2004) [PubMed] [Europe PMC] [Abstract]
  13. "HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype."Blood 103:2835-2840(2004) [PubMed] [Europe PMC] [Abstract]
  14. "A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis."Clin. Genet. 65:378-383(2004) [PubMed] [Europe PMC] [Abstract]