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Xeroderma Pigmentosum, Complementation Group D (XPD)

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CXPD; BTF2 p80; EM9; TTD; ERCC2; TFIIH basal transcription factor complex 80 kDa; De Sanctis-Cacchione; Excision Repair Cross-Complementing Rodent Repair Deficiency 2

Xeroderma Pigmentosum, Complementation Group D (XPD)
CCC C013
HGNC 3434
MGI 95413
PubMed 1729695
UniProt P18074
Wiki ERCC2

ERCC2, or XPD is a protein involved in transcription-coupled nucleotide excision repair.The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 exons and 21 introns. The XPD protein is a 760 amino acids polypeptide with a size of 87kDa. Defects in this gene can result in three different disorders: the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome.

Just like XPB, XPD is also a part of human transcriptional initiation factor TFIIH and has ATP-dependent helicase activity. It belongs to the RAD3/XPD subfamily of helicases.XPD is essential for the viability of cells. Deletion of XPD in mice is embryonic lethal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC013Hu01 Recombinant Xeroderma Pigmentosum, Complementation Group D (XPD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC013Hu01 Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group D (XPD) WB; IHC; ICC; IP.
Assay Kits SEC013Hu ELISA Kit for Xeroderma Pigmentosum, Complementation Group D (XPD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Xeroderma Pigmentosum, Complementation Group D (XPD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group D (XPD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group D (XPD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xeroderma Pigmentosum, Complementation Group D (XPD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xeroderma Pigmentosum, Complementation Group D (XPD) ELISA Kit Customized Service Offer
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  13. "MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
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  20. "Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy."Am. J. Hum. Genet. 58:263-270(1996) [PubMed] [Europe PMC] [Abstract]
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