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Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin.
In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.The 176-amino acid IL20 protein contains 6 conserved cysteine residues and shares 76% amino acid identity with its murine counterpart. Based on amino acid identities, IL20 is most homologous to 3 members of the IL10 family, IL19 , MDA7 , and IL10.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC058Hu01 | Recombinant Interleukin 20 (IL20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APC058Hu01 | Active Interleukin 20 (IL20) | Cell culture; Activity Assays. | |
| Antibodies | PAC058Hu01 | Polyclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. |
| MAC058Hu22 | Monoclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC058Hu | ELISA Kit for Interleukin 20 (IL20) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC058Hu | CLIA Kit for Interleukin 20 (IL20) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC058Mu01 | Recombinant Interleukin 20 (IL20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC058Mu02 | Recombinant Interleukin 20 (IL20) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPC058Mu61 | Eukaryotic Interleukin 20 (IL20) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC058Mu61 | Active Interleukin 20 (IL20) | Cell culture; Activity Assays. | |
| Antibodies | PAC058Mu01 | Polyclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. |
| PAC058Mu02 | Polyclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC058Mu | ELISA Kit for Interleukin 20 (IL20) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC058Ra01 | Recombinant Interleukin 20 (IL20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC058Ra01 | Polyclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. |
| MAC058Ra21 | Monoclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC058Ra | ELISA Kit for Interleukin 20 (IL20) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC058Ra | CLIA Kit for Interleukin 20 (IL20) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC058Eq01 | Recombinant Interleukin 20 (IL20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC058Eq01 | Polyclonal Antibody to Interleukin 20 (IL20) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Interleukin 20 (IL20) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Interleukin 20 (IL20) | ELISA Kit Customized Service Offer |
- "Interleukin 20: discovery, receptor identification, and role in epidermal function." Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract]
- "Interleukin-20 promotes angiogenesis in a direct and indirect manner."Genes Immun. 7:234-242(2006) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "Tissue microarray analysis of interleukin-20 expression."Cytokine 35:44-52(2006) [PubMed] [Europe PMC] [Abstract]
- "Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes."Photochem. Photobiol. 82:1292-1300(2006) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]