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Interferon Inducible T-Cell Alpha Chemoattractant (ITaC)

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CXCL11; I-TAC; IP9; SCYB11; SCYB9B; B-R1; Chemokine(C-X-C-Motif)ligand 11; Small Inducible Cytokine Subfamily B Member 11; Interferon gamma-inducible protein 9

Interferon Inducible T-Cell Alpha Chemoattractant (ITaC)
CCC C071
HGNC 10638
MGI 1860203
PubMed 15178708
RGD 727827
UniProt O14625
Wiki CXCL11

Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.

Gene expression of CXCL11 is strongly induced by IFN-gamma and IFN-beta, and weakly induced by IFN-alpha.This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.CXCL11 is chemotactic for activated T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC071Hu01 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
RPC071Hu02 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
APC071Hu01 Active Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Cell culture; Activity Assays.
Antibodies PAC071Hu01 Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
LAC071Hu71 Biotin-Linked Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC.
MAC071Hu21 Monoclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
PAC071Hu02 Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
Assay Kits SEC071Hu ELISA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC071Hu CLIA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC071Mu01 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
RPC071Mu02 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC071Mu01 Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
PAC071Mu02 Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
Assay Kits SEC071Mu ELISA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC071Mu CLIA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC071Ra01 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC071Ra01 Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
MAC071Ra21 Monoclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
Assay Kits SEC071Ra ELISA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC071Ra CLIA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Hamster (Chinese hamster)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC071Ha01 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC071Si01 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC071Bo01 Recombinant Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC071Bo01 Polyclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
MAC071Bo21 Monoclonal Antibody to Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) WB; IHC; ICC; IP.
Assay Kits SEC071Bo ELISA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC071Bo CLIA Kit for Interferon Inducible T-Cell Alpha Chemoattractant (ITaC) Chemiluminescent immunoassay for Antigen Detection.
  1. "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha."J. Biol. Chem. 271:22878-22884(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A genetic selection for isolating cDNAs encoding secreted proteins."Gene 198:289-296(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3."J. Exp. Med. 187:2009-2021(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)."J. Interferon Cytokine Res. 19:505-513(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene."Biochim. Biophys. Acta 1446:167-172(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)."Cytogenet. Cell Genet. 81:271-272(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation."Blood 112:2648-2656(2008) [PubMed] [Europe PMC] [Abstract]
  10. "NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)."Protein Sci. 13:2022-2028(2004) [PubMed] [Europe PMC] [Abstract]