≡

Laminin Gamma 1 (LAMC1)

[Edit]

LAM-C1; LAMB2; S-laminin subunit gamma; Laminin B2 chain

Laminin Gamma 1 (LAMC1)
CCC C082
HGNC 6492
MGI 99914
PubMed 9917858
RGD 621052
UniProt P11047
Wiki LAMC1

LAMC1 is the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs seen on Northern analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC082Hu01 Recombinant Laminin Gamma 1 (LAMC1) Positive Control; Immunogen; SDS-PAGE; WB.
APC082Hu01 Active Laminin Gamma 1 (LAMC1) Cell culture; Activity Assays.
Antibodies PAC082Hu01 Polyclonal Antibody to Laminin Gamma 1 (LAMC1) WB
MAC082Hu22 Monoclonal Antibody to Laminin Gamma 1 (LAMC1) WB; IHC; ICC; IP.
LAC082Hu71 Biotin-Linked Polyclonal Antibody to Laminin Gamma 1 (LAMC1) WB; IHC; ICC.
Assay Kits SEC082Hu ELISA Kit for Laminin Gamma 1 (LAMC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC082Mu01 Recombinant Laminin Gamma 1 (LAMC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC082Mu01 Polyclonal Antibody to Laminin Gamma 1 (LAMC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Laminin Gamma 1 (LAMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Gamma 1 (LAMC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC082Ra01 Recombinant Laminin Gamma 1 (LAMC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC082Ra01 Polyclonal Antibody to Laminin Gamma 1 (LAMC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Laminin Gamma 1 (LAMC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Gamma 1 (LAMC1) ELISA Kit Customized Service Offer
  1. "Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains."J. Biol. Chem. 263:6751-6758(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene."J. Biol. Chem. 266:221-228(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Differences in human laminin B2 sequences."DNA Seq. 1:275-277(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31."Cytogenet. Cell Genet. 48:137-141(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]