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Integrin Alpha 7 (ITGa7)

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ITG-A7

Integrin Alpha 7 (ITGa7)
CCC C093
HGNC 6143
MGI 102700
PubMed 7607681
RGD 71022
UniProt Q13683
Wiki ITGA7

ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells.

Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC093Hu01 Recombinant Integrin Alpha 7 (ITGa7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC093Hu01 Polyclonal Antibody to Integrin Alpha 7 (ITGa7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha 7 (ITGa7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 7 (ITGa7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Alpha 7 (ITGa7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Alpha 7 (ITGa7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Alpha 7 (ITGa7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Alpha 7 (ITGa7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 7 (ITGa7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Alpha 7 (ITGa7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Alpha 7 (ITGa7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Alpha 7 (ITGa7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Alpha 7 (ITGa7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 7 (ITGa7) ELISA Kit Customized Service Offer
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  2. "Mutations in the integrin alpha7 gene cause congenital myopathy."Nat. Genet. 19:94-97(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7)."Biochem. Biophys. Res. Commun. 260:357-364(1999) [PubMed] [Europe PMC] [Abstract]
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  9. "Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation."Gastroenterology 113:1510-1521(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes."Cell Regul. 2:805-817(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain."Mol. Biol. Cell 8:1723-1734(1997) [PubMed] [Europe PMC] [Abstract]
  13. "The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins."Exp. Cell Res. 255:303-313(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction."Dev. Biol. 174:125-139(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes."Am. J. Respir. Cell Mol. Biol. 37:668-680(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function."J. Biol. Chem. 283:35668-35678(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences."Biochem. Cell Biol. 90:646-656(2012) [PubMed] [Europe PMC] [Abstract]