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Bone Morphogenetic Protein 3 (BMP3)

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BMP3A; BMP-3A; Osteogenic

Bone Morphogenetic Protein 3 (BMP3)
CCC C102
HGNC 1070
MGI 88179
PubMed 20143330
RGD 2212
UniProt P12645
Wiki BMP3

Bone morphogenetic protein 3 is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts. Expressed in adult and fetal cartilage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC102Hu01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC102Hu01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
MAC102Hu22 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
Assay Kits SEC102Hu ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPC102Mu61 Eukaryotic Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPC102Mu01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
APC102Mu61 Active Bone Morphogenetic Protein 3 (BMP3) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) Polyclonal Antibody Customized Service Offer
Assay Kits SEC102Mu ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC102Ra01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC102Ra01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
MAC102Ra21 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
MAC102Ra22 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC102Bo01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC102Bo01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
MAC102Bo21 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC
MAC102Bo22 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
MAC102Bo23 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) ELISA Kit Customized Service Offer
  1. "Novel regulators of bone formation: molecular clones and activities."Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Bone morphogenetic protein-3 is a negative regulator of bone density."Nat. Genet. 27:84-88(2001) [PubMed] [Europe PMC] [Abstract]
  5. "BMP signaling components are expressed in human fracture callus."Bone 33:362-371(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery."Gene Ther. 11:1312-1320(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage."J. Orthop. Res. 22:1188-1192(2004) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors."Biochemistry 46:12238-12247(2007) [PubMed] [Europe PMC] [Abstract]