Bone Morphogenetic Protein 10 (BMP10)
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Bone morphogenetic protein 10 (BMP10) is a polypeptide belonging to the TGF-beta superfamily of proteins.It is a novel protein that, unlike most other BMP's, is likely to be involved in the tabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-beta superfamily.
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Inhibits endothelial cell migration and growth.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC106Mu01 | Recombinant Bone Morphogenetic Protein 10 (BMP10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC106Mu02 | Recombinant Bone Morphogenetic Protein 10 (BMP10) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC106Mu01 | Polyclonal Antibody to Bone Morphogenetic Protein 10 (BMP10) | WB; IHC; ICC; IP. |
| PAC106Mu02 | Polyclonal Antibody to Bone Morphogenetic Protein 10 (BMP10) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC106Mu | ELISA Kit for Bone Morphogenetic Protein 10 (BMP10) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC106Mu | CLIA Kit for Bone Morphogenetic Protein 10 (BMP10) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Bone Morphogenetic Protein 10 (BMP10) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Bone Morphogenetic Protein 10 (BMP10) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Bone Morphogenetic Protein 10 (BMP10) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEC106Ra | ELISA Kit for Bone Morphogenetic Protein 10 (BMP10) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses."J. Biol. Chem. 280:32122-32132(2005) [PubMed] [Europe PMC] [Abstract]
- "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells."Blood 109:1953-1961(2007) [PubMed] [Europe PMC] [Abstract]
- "Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer."Cancer Sci. 101:2137-2144(2010) [PubMed] [Europe PMC] [Abstract]