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Activin A Receptor Type II B (ACVR2B)

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ACVR2-B; ActR-IIB

Activin A Receptor Type II B (ACVR2B)
CCC C118
HGNC 174
MGI 87912
PubMed 9916847
RGD 2028
UniProt Q13705
Wiki ACVR2B

ACVR2B is an activin type 2 receptor. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.

Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activin A Receptor Type II B (ACVR2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activin A Receptor Type II B (ACVR2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) Polyclonal Antibody Customized Service Offer
Assay Kits SEC118Hu ELISA Kit for Activin A Receptor Type II B (ACVR2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC118Mu01 Recombinant Activin A Receptor Type II B (ACVR2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC118Mu01 Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) WB; IHC; ICC; IP.
LAC118Mu71 Biotin-Linked Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) WB; IHC; ICC.
Assay Kits SEC118Mu ELISA Kit for Activin A Receptor Type II B (ACVR2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC118Ra01 Recombinant Activin A Receptor Type II B (ACVR2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC118Ra01 Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) WB; IHC; ICC; IP.
LAC118Ra71 Biotin-Linked Polyclonal Antibody to Activin A Receptor Type II B (ACVR2B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Activin A Receptor Type II B (ACVR2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activin A Receptor Type II B (ACVR2B) ELISA Kit Customized Service Offer
  1. "Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor."Blood 83:2163-2170(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene."J. Hum. Genet. 43:132-134(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB."Am. J. Med. Genet. 82:70-76(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Activation of signalling by the activin receptor complex."Mol. Cell. Biol. 16:1066-1073(1996) [PubMed] [Europe PMC] [Abstract]
  6. "TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling."EMBO J. 22:4465-4477(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."J. Biol. Chem. 287:27313-27325(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]