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SMAD family member 6 (SMAD6)

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MADH6; MADH7; Mothers Against Decapentaplegic Homolog 6

SMAD family member 6 (SMAD6)
CCC C120
HGNC 6772
MGI 1336883
PubMed 9335505
RGD 1305069
UniProt O43541
Wiki SMAD6

SMAD family member 6, also known as SMAD6 is a protein that, as its name describes, is a homolog of the Drosophila gene "mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF beta superfamily of modulators.

Like many other TGF beta family members SMAD6 is involved in cell signalling. It acts as a regulator of TGF beta family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the transcription of SMAD4's gene products. There are two known isoforms of this protein.The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The name is a combination of the two.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC120Hu01 Recombinant SMAD family member 6 (SMAD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC120Hu01 Polyclonal Antibody to SMAD family member 6 (SMAD6) WB; IHC; ICC; IP.
Assay Kits SEC120Hu ELISA Kit for SMAD family member 6 (SMAD6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC120Mu01 Recombinant SMAD family member 6 (SMAD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC120Mu01 Polyclonal Antibody to SMAD family member 6 (SMAD6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for SMAD family member 6 (SMAD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for SMAD family member 6 (SMAD6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC120Ra01 Recombinant SMAD family member 6 (SMAD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC120Ra01 Polyclonal Antibody to SMAD family member 6 (SMAD6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for SMAD family member 6 (SMAD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for SMAD family member 6 (SMAD6) ELISA Kit Customized Service Offer
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  15. "Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation."Hum. Mutat. 33:720-727(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6."EMBO J. 32:996-1007(2013) [PubMed] [Europe PMC] [Abstract]