SMAD family member 9 (SMAD9)
[Edit]MADH2; MADR2; Madh6; Mothers against DPP homolog 9; Mothers Against Decapentaplegic Homolog 9
SMAD9 or Mothers against decapentaplegic homolog 9 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members, SMAD9 is involved in cell signalling.
When a bone morphogenetic protein binds to a receptor (BMP type 1 receptor kinase) it causes SMAD9 to interact with SMAD anchor for receptor activation (SARA).The binding of ligands causes the phosphorylation of the SMAD9 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC121Hu01 | Recombinant SMAD family member 9 (SMAD9) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC121Hu01 | Polyclonal Antibody to SMAD family member 9 (SMAD9) | WB; IHC; ICC/IF |
Assay Kits | SEC121Hu | ELISA Kit for SMAD family member 9 (SMAD9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant SMAD family member 9 (SMAD9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to SMAD family member 9 (SMAD9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to SMAD family member 9 (SMAD9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for SMAD family member 9 (SMAD9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for SMAD family member 9 (SMAD9) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant SMAD family member 9 (SMAD9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to SMAD family member 9 (SMAD9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to SMAD family member 9 (SMAD9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for SMAD family member 9 (SMAD9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for SMAD family member 9 (SMAD9) | ELISA Kit Customized Service Offer |
- "Cloning and characterization of a novel member of the human Mad gene family (MADH6)."Genomics 42:446-451(1997) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "TGF-beta signal transduction."Annu. Rev. Biochem. 67:753-791(1998) [PubMed] [Europe PMC] [Abstract]
- "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells."Cytokine Growth Factor Rev. 10:187-199(1999) [PubMed] [Europe PMC] [Abstract]
- "The Smad pathway."Cytokine Growth Factor Rev. 11:5-13(2000) [PubMed] [Europe PMC] [Abstract]
- "TGF-beta signaling by Smad proteins."Cytokine Growth Factor Rev. 11:15-22(2000) [PubMed] [Europe PMC] [Abstract]
- "Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension." Hum. Mutat. 32:1385-1389(2011) [PubMed] [Europe PMC] [Abstract]