Chordin (CHRD)
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Chordin is a polypeptide that dorsalizes the developing embryo by binding ventralizing TGFbeta proteins such as bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.In humans, the chordin peptide is encoded by the CHRD gene.
948-amino acid protein containing 4 internal cysteine-rich repeats and 4 potential N-glycosylation sites. Northern blot analysis detected high levels of a 3.7-kb Chrd transcript in 7-day postcoitum mouse embryos; its level decreased at later developmental stages and in adult tissues. Dot blot analysis of mRNA expression in human adult and fetal tissues showed that CHRD is expressed at the highest level in liver.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC126Hu01 | Recombinant Chordin (CHRD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC126Hu01 | Polyclonal Antibody to Chordin (CHRD) | WB; IHC; ICC; IP. |
| Assay Kits | SEC126Hu | ELISA Kit for Chordin (CHRD) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC126Mu01 | Recombinant Chordin (CHRD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC126Mu01 | Polyclonal Antibody to Chordin (CHRD) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Chordin (CHRD) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Chordin (CHRD) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC126Ra01 | Recombinant Chordin (CHRD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC126Ra01 | Polyclonal Antibody to Chordin (CHRD) | WB; IHC; ICC; IP. |
| MAC126Ra21 | Monoclonal Antibody to Chordin (CHRD) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC126Ra | ELISA Kit for Chordin (CHRD) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities."Mech. Dev. 106:85-96(2001) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes."Genomics 52:236-239(1998) [PubMed] [Europe PMC] [Abstract]
- "BMP-binding modules in chordin: a model for signalling regulation in the extracellular space."Development 127:821-830(2000) [PubMed] [Europe PMC] [Abstract]
- "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]