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Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1)

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TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1

Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1)
CCC C129
HGNC 6714
MGI 109151
PubMed 12711389
RGD 68379
UniProt Q14766
Wiki LTBP1

Latent-transforming growth factor beta-binding protein 1  belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins.

The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC129Hu01 Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC129Hu01 Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) WB; IHC; ICC; IP.
Assay Kits SEC129Hu ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC129Mu01 Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC129Mu02 Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC129Mu01 Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) WB; IHC
PAC129Mu02 Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) WB; IHC; ICC; IP.
Assay Kits SEC129Mu ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) ELISA Kit Customized Service Offer
  1. "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences."Cell 61:1051-1061(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix."J. Biol. Chem. 270:31294-31297(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Latent transforming growth factor-beta binding proteins (LTBPs) --structural extracellular matrix proteins for targeting TGF-beta action."Cytokine Growth Factor Rev. 10:99-117(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The latent transforming growth factor beta binding protein (LTBP) family."Biochem. J. 352:601-610(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells."Biochemistry 39:1596-1603(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta."Mol. Biol. Cell 11:2691-2704(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein."J. Biol. Chem. 278:2750-2757(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation."Nat. Genet. 40:1119-1123(2008) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta."J. Mol. Biol. 334:281-291(2003) [PubMed] [Europe PMC] [Abstract]