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Collagen Type IV Alpha 2 (COL4a2)

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COL4-A2; Canstatin; Collagen Alpha-2(IV)chain

Collagen Type IV Alpha 2 (COL4a2)
CCC C144
HGNC 2203
MGI 88455
PubMed 22333902
RGD 1308085
UniProt P08572
Wiki COL4A2

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC144Hu01 Recombinant Collagen Type IV Alpha 2 (COL4a2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC144Hu01 Polyclonal Antibody to Collagen Type IV Alpha 2 (COL4a2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 2 (COL4a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 2 (COL4a2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 2 (COL4a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 2 (COL4a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 2 (COL4a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 2 (COL4a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 2 (COL4a2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 2 (COL4a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 2 (COL4a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 2 (COL4a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 2 (COL4a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 2 (COL4a2) ELISA Kit Customized Service Offer
  1. "The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain."J. Biol. Chem. 263:19488-19493(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain."Eur. J. Biochem. 172:35-42(1988) [PubMed] [Europe PMC] [Abstract]
  4. "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure."EMBO J. 7:2687-2695(1988) [PubMed] [Europe PMC] [Abstract]
  5. "The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region."J. Biol. Chem. 263:17217-17220(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription."Biochem. J. 292:687-695(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2)."Hum. Genet. 77:318-324(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region."FEBS Lett. 216:281-286(1987) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13."Proc. Natl. Acad. Sci. U.S.A. 84:512-516(1987) [PubMed] [Europe PMC] [Abstract]
  11. "The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen."Eur. J. Biochem. 176:617-624(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes."J. Biol. Chem. 262:9231-9238(1987) [PubMed] [Europe PMC] [Abstract]
  13. "Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth."J. Biol. Chem. 275:1209-1215(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells."J. Biol. Chem. 278:37632-37636(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins."Cancer Res. 65:4353-4361(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link."Proc. Natl. Acad. Sci. U.S.A. 99:6607-6612(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus."Mol. Vis. 17:827-843(2011) [PubMed] [Europe PMC] [Abstract]
  20. "De novo and inherited mutations in COL4A2, encoding the type IV collagen alpha2 chain cause porencephaly."Am. J. Hum. Genet. 90:86-90(2012) [PubMed] [Europe PMC] [Abstract]
  21. "COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke."Am. J. Hum. Genet. 90:91-101(2012) [PubMed] [Europe PMC] [Abstract]
  22. "COL4A2 mutation associated with familial porencephaly and small-vessel disease."Eur. J. Hum. Genet. 20:844-851(2012) [PubMed] [Europe PMC] [Abstract]