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Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1)

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HLA-DQA1; HLADQA1; GSE; CD; CELIAC1; HLA-DCA; DQ-A1; HLA-DQA; DC-1 alpha chain; HLA Class II Histocompatibility Antigen,DQ Alpha 1 Chain

Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1)
CCC C163
HGNC 4942
MGI 95895
PubMed 15301863
RGD 1595867
UniProt P01907
Wiki HLA-DQA1

Major histocompatibility complex, class II, DQ alpha 1 is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The alpha chain contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DQ Alpha 1 (MHCDQa1) ELISA Kit Customized Service Offer
  1. "The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region."Nature 305:813-815(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains."EMBO J. 3:447-452(1984) [PubMed] [Europe PMC] [Abstract]
  3. "Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes."Nature 308:327-333(1984) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line."J. Immunol. 139:228-233(1987) [PubMed] [Europe PMC] [Abstract]
  5. "HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy."Immunogenetics 46:410-417(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Ancient haplotypes of the HLA Class II region."Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Four novel human leukocyte antigen-DQA1 alleles identified in the Korean population."Tissue Antigens 68:167-172(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications."Proc. Natl. Acad. Sci. U.S.A. 82:3420-3424(1985) [PubMed] [Europe PMC] [Abstract]
  13. "MHC class II sequences of an HLA-DR2 narcoleptic."Immunogenetics 27:449-455(1988) [PubMed] [Europe PMC] [Abstract]
  14. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1)."Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3."J. Immunol. 142:1743-1747(1989) [PubMed] [Europe PMC] [Abstract]
  17. "High-resolution genotyping of HLA-DQA1 in the GoKinD study and identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-DQA1*0404."Tissue Antigens 65:448-458(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals."Hum. Immunol. 21:249-263(1988) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of a novel HLA-DQA1 allele (DQA1*0106) by sequence-based DQA1 typing."Tissue Antigens 53:595-596(1999) [PubMed] [Europe PMC] [Abstract]
  20. "HLA class II nucleotide sequences, 1992."Tissue Antigens 40:229-243(1992) [PubMed] [Europe PMC] [Abstract]
  21. "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes."J. Immunol. 140:3631-3639(1988) [PubMed] [Europe PMC] [Abstract]
  22. ErratumJ. Immunol. 144:15441-15441(1990)
  23. "cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong sequence homology to the HLA-DR heavy chain."Proc. Natl. Acad. Sci. U.S.A. 79:6337-6341(1982) [PubMed] [Europe PMC] [Abstract]
  24. "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates."Proc. Natl. Acad. Sci. U.S.A. 86:9986-9990(1989) [PubMed] [Europe PMC] [Abstract]
  25. "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers."Immunogenetics 26:282-290(1987) [PubMed] [Europe PMC] [Abstract]
  26. "Invariant chain structure and MHC class II function."Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
  27. "Presentation of antigens by MHC class II molecules: getting the most out of them."Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
  28. "Autophagy in MHC class II presentation: sampling from within."Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
  29. "MHC class II molecules on the move for successful antigen presentation."EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
  30. "MHC class II transport at a glance."J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
  31. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes."Nat. Immunol. 2:501-507(2001) [PubMed] [Europe PMC] [Abstract]
  33. "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]
  34. "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease."Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004) [PubMed] [Europe PMC] [Abstract]
  35. "A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease."Immunity 27:23-34(2007) [PubMed] [Europe PMC] [Abstract]