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Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2)

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HLA-DQA2; HLADQa2; DQ Alpha; HLA-DXA; HLA Class II Histocompatibility Antigen,DQ(6)Alpha Chain

Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2)
CCC C164
HGNC 4943
PubMed 9036956
UniProt P01906
Wiki HLA-DQA2

HLA class II histocompatibility antigen, DQ(6) alpha chain is expressed, but unlike HLA-DQA1, it apparently unable to heterodimerize with HLA class II beta chain paralogues.The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.

The alpha chain contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DQ Alpha 2 (MHCDQa2) ELISA Kit Customized Service Offer
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