≡

HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA)

[Edit]

MHCDRa; HLADRa; Major Histocompatibility Complex Class II DR Alpha

HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA)
CCC C166
HGNC 4947
MGI 95900
PubMed 22391069
RGD 1593283
UniProt P01903
Wiki HLA-DRA

Major histocompatibility complex, class II, DR alpha is the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. However it can pair with, in any individual, the beta chain from 3 different DR beta loci, DRB1, and two of any DRB3, DRB4, or DRB5 alleles. Thus there is the potential that any given individual can form 4 different HLA-DR isoforms (2 alleles of DRB1 and two alleles from DRB3, DRB4 or DRB5).The polypeptide subunit encoded by this gene belongs to the HLA class II alpha chain paralogues. The class II protein is a heterodimer consisting of an alpha (DRα) and a beta chain (DRβ), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC166Hu01 Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC166Hu01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB
LAC166Hu71 Biotin-Linked Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC.
MAC166Hu21 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
MAC166Hu22 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC166Rb01 Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC166Rb51 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB,IHC
PAC166Rb01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC166Si01 Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC166Si01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
LAC166Si71 Biotin-Linked Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC.
MAC166Si21 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
MAC166Si22 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC166Ca01 Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC166Ca01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC166Po01 Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC166Po01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC166Bo01 Recombinant HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC166Bo01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DRA) ELISA Kit Customized Service Offer
  1. "Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene."Nature 299:750-752(1982) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning the heavy chain of human HLA-DR antigen using synthetic oligodeoxyribonucleotides as hybridization probes."DNA 2:175-182(1983) [PubMed] [Europe PMC] [Abstract]
  3. "Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain."Nucleic Acids Res. 11:8663-8675(1983) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and nucleotide sequence of the heavy chain gene of HLA-DR."Proc. Natl. Acad. Sci. U.S.A. 80:3543-3547(1983) [PubMed] [Europe PMC] [Abstract]
  5. ErratumProc. Natl. Acad. Sci. U.S.A. 80:7024-7024(1983)
  6. "Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain."J. Immunol. 145:2730-2736(1990) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Primary structure of class II human histocompatibility antigens. 2nd Communication. Amino acid sequence of the N-terminal 179 residues of the alpha-chain of an HLA-Dw2/DR2 alloantigen."Hoppe-Seyler's Z. Physiol. Chem. 363:671-676(1982) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens."Biochemistry 22:185-188(1983) [PubMed] [Europe PMC] [Abstract]
  11. "Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins."Cell 30:153-161(1982) [PubMed] [Europe PMC] [Abstract]
  12. "The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins."Proc. Natl. Acad. Sci. U.S.A. 79:6013-6017(1982) [PubMed] [Europe PMC] [Abstract]
  13. "The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes."Tissue Antigens 60:266-267(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Heterozygote advantage for HLA class-II type in hepatitis B virus infection."Nat. Genet. 17:11-12(1997) [PubMed] [Europe PMC] [Abstract]
  15. ErratumNat. Genet. 18:88-88(1998)
  16. "Invariant chain structure and MHC class II function."Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
  17. "Presentation of antigens by MHC class II molecules: getting the most out of them."Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
  18. "MHC class II molecules on the move for successful antigen presentation."EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Autophagy in MHC class II presentation: sampling from within."Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
  20. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
  21. "MHC class II transport at a glance."J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
  22. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
  23. "The HLA-DRalpha chain is modified by polyubiquitination."J. Biol. Chem. 284:7007-7016(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1."Nature 364:33-39(1993) [PubMed] [Europe PMC] [Abstract]
  28. "Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide."Nature 368:215-221(1994) [PubMed] [Europe PMC] [Abstract]
  29. "Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen."Nature 368:711-718(1994) [PubMed] [Europe PMC] [Abstract]
  30. "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3."Nature 378:457-462(1995) [PubMed] [Europe PMC] [Abstract]
  31. "X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II."Immunity 7:473-481(1997) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein."J. Exp. Med. 188:1511-1520(1998) [PubMed] [Europe PMC] [Abstract]
  33. "Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins."J. Mol. Biol. 304:177-188(2000) [PubMed] [Europe PMC] [Abstract]
  34. "Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II."Immunity 14:93-104(2001) [PubMed] [Europe PMC] [Abstract]
  35. "A functional and structural basis for TCR cross-reactivity in multiple sclerosis."Nat. Immunol. 3:940-943(2002) [PubMed] [Europe PMC] [Abstract]
  36. "Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule."EMBO J. 24:2968-2979(2005) [PubMed] [Europe PMC] [Abstract]
  37. "Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."J. Mol. Biol. 371:435-446(2007) [PubMed] [Europe PMC] [Abstract]
  38. "The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles."Proc. Natl. Acad. Sci. U.S.A. 105:11893-11897(2008) [PubMed] [Europe PMC] [Abstract]