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HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1)

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HLA-DRB1; MHCDRb1; HLADRb1; Major Histocompatibility Complex Class II DR Beta 1; HLA Class II Histocompatibility Antigen,DRB1-9 Beta Chain; HLA class II histocompatibility antigen, DRB1-15 beta chain

HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1)
CCC C167
HGNC 4948
MGI 95901
PubMed 16447236
RGD 1593282
UniProt P01911
Wiki HLA-DRB1

  • HLA class II histocompatibility antigen, DRB1-9 beta chain belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

  • The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC167Hu01 Recombinant HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC167Hu01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC
MAC167Hu21 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC
MAC167Hu22 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB
MAC167Hu23 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC; ICC; IP.
MAC167Hu25 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC; ICC; IP.
MAC167Hu24 Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC; ICC; IP.
Assay Kits SEC167Hu ELISA Kit for HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC167Mu01 Recombinant HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC167Mu02 Recombinant HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC167Mu01 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC; ICC; IP.
PAC167Mu02 Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) WB; IHC; ICC; IP.
Assay Kits SEC167Mu ELISA Kit for HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HLA Class II Histocompatibility Antigen, DRB1 Beta Chain (HLA-DRB1) ELISA Kit Customized Service Offer
  1. "MHC class II sequences of an HLA-DR2 narcoleptic."Immunogenetics 27:449-455(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Ancient haplotypes of the HLA Class II region."Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
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  7. "HLA-DR2 subtypes form an additional supertypic family of DR beta alleles."Proc. Natl. Acad. Sci. U.S.A. 84:4591-4595(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Allelic variation in the DR subregion of the human major histocompatibility complex."Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen."Hoppe-Seyler's Z. Physiol. Chem. 362:1665-1669(1981) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens."Biochemistry 22:185-188(1983) [PubMed] [Europe PMC] [Abstract]
  11. "Invariant chain structure and MHC class II function."Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Presentation of antigens by MHC class II molecules: getting the most out of them."Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Autophagy in MHC class II presentation: sampling from within."Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
  14. "MHC class II molecules on the move for successful antigen presentation."EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
  15. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
  16. "MHC class II transport at a glance."J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
  17. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor."Nat. Immunol. 6:490-496(2005) [PubMed] [Europe PMC] [Abstract]