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Interferon Regulatory Factor 2 (IRF2)

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Interferon Regulatory Factor 2 (IRF2)
CCC C180
HGNC 6117
MGI 96591
PubMed 15086546
RGD 1304922
UniProt P14316
Wiki IRF2
Interferon regulatory factor 2 isa member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Harada et al. (1993) found that when the IRF2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. This transformed phenotype was reversed by concomitant expression of the IRF1 gene. Thus, restrained cell growth depends on a balance between these 2 mutually antagonistic transcription factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC180Hu01 Recombinant Interferon Regulatory Factor 2 (IRF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC180Hu01 Polyclonal Antibody to Interferon Regulatory Factor 2 (IRF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 (IRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 (IRF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC180Mu01 Recombinant Interferon Regulatory Factor 2 (IRF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC180Mu01 Polyclonal Antibody to Interferon Regulatory Factor 2 (IRF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 (IRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 (IRF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 2 (IRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 2 (IRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 2 (IRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 (IRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 (IRF2) ELISA Kit Customized Service Offer
  1. "Sequence of a cDNA coding for human IRF-2."Nucleic Acids Res. 17:8372-8372(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region."J. Biol. Chem. 269:5279-5287(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes."Mol. Biol. Rep. 25:1-12(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2."J. Cell. Physiol. 185:269-279(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning of an interferon regulatory factor 2 isoform with different regulatory ability."Nucleic Acids Res. 28:4219-4224(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interferon regulatory factor-2 regulates cell growth through its acetylation."J. Biol. Chem. 278:25401-25407(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of novel co-repressor molecules for interferon regulatory factor-2."Nucleic Acids Res. 31:3016-3026(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells."Mol. Cell. Biol. 24:6298-6310(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of IRF2 transcriptional activity by its sumoylation."Biochem. Biophys. Res. Commun. 372:772-778(2008) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]