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Interferon Regulatory Factor 7 (IRF7)

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IRF7-A; IRF7A

Interferon Regulatory Factor 7 (IRF7)
CCC C181
HGNC 6122
MGI 1859212
PubMed 23490048
RGD 1307828
UniProt Q92985
Wiki IRF7
Interferon regulatory factor 7 is a member of the interferon regulatory factor family of transcription factors.IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 7 (IRF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 7 (IRF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 7 (IRF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 7 (IRF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 7 (IRF7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 7 (IRF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 7 (IRF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 7 (IRF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 7 (IRF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 7 (IRF7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 7 (IRF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 7 (IRF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 7 (IRF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 7 (IRF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 7 (IRF7) ELISA Kit Customized Service Offer
  1. "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency."Mol. Cell. Biol. 17:5748-5757(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes."J. Biol. Chem. 273:29210-29217(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain."Mol. Cell. Biol. 20:8803-8814(2000) [PubMed] [Europe PMC] [Abstract]
  5. "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein."J. Biol. Chem. 276:8951-8957(2001) [PubMed] [Europe PMC] [Abstract]
  6. "HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators."Oncogene 20:800-811(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding."J. Biol. Chem. 277:49417-49421(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and function of IRF-7."J. Interferon Cytokine Res. 22:95-101(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation."Proc. Natl. Acad. Sci. U.S.A. 99:5573-5578(2002) [PubMed] [Europe PMC] [Abstract]
  10. "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF."J. Exp. Med. 198:1043-1055(2003) [PubMed] [Europe PMC] [Abstract]
  11. ErratumJ. Exp. Med. 198:1451-1451(2003)
  12. "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
  13. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity."J. Virol. 78:10636-10649(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling."Proc. Natl. Acad. Sci. U.S.A. 101:15416-15421(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6."Nat. Immunol. 5:1061-1068(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction."J. Exp. Med. 201:915-923(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages."Biochem. Pharmacol. 72:1469-1476(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Type I interferon gene induction by the interferon regulatory factor family of transcription factors."Immunity 25:349-360(2006) [PubMed] [Europe PMC] [Abstract]
  20. ErratumImmunity 25:849-849(2006)
  21. "IRF-7: new role in the regulation of genes involved in adaptive immunity."Ann. N. Y. Acad. Sci. 1095:325-333(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7."J. Virol. 81:4473-4481(2007) [PubMed] [Europe PMC] [Abstract]
  23. "IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3."Proc. Natl. Acad. Sci. U.S.A. 105:18448-18453(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Epstein-Barr virus LF2: an antagonist to type I interferon."J. Virol. 83:1140-1146(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Regulation of immunity and oncogenesis by the IRF transcription factor family."Cancer Immunol. Immunother. 59:489-510(2010) [PubMed] [Europe PMC] [Abstract]
  26. "IRF7: activation, regulation, modification and function."Genes Immun. 12:399-414(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7."J. Immunol. 187:4754-4763(2011) [PubMed] [Europe PMC] [Abstract]