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Amphiphysin is a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.
Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis.
Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC205Hu01 | Recombinant Amphiphysin (AMPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC205Hu01 | Polyclonal Antibody to Amphiphysin (AMPH) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Amphiphysin (AMPH) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Amphiphysin (AMPH) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC205Mu01 | Recombinant Amphiphysin (AMPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC205Mu01 | Polyclonal Antibody to Amphiphysin (AMPH) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Amphiphysin (AMPH) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Amphiphysin (AMPH) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC205Ra01 | Recombinant Amphiphysin (AMPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC205Ra01 | Polyclonal Antibody to Amphiphysin (AMPH) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Amphiphysin (AMPH) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Amphiphysin (AMPH) | ELISA Kit Customized Service Offer |
- "Autoimmunity in stiff-man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161."FEBS Lett. 351:73-79(1994) [PubMed] [Europe PMC] [Abstract]
- "Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14."Hum. Mol. Genet. 4:265-268(1995) [PubMed] [Europe PMC] [Abstract]
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- "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits."Biochem. Biophys. Res. Commun. 402:408-413(2010) [PubMed] [Europe PMC] [Abstract]
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