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Histone Deacetylase 2 (HDAC2)

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RPD3; YAF1; HD2

Histone Deacetylase 2 (HDAC2)
CCC C210
HGNC 4853
MGI 1097691
PubMed 22492270
RGD 619976
UniProt Q92769
Wiki HDAC2
Histone deacetylase 2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.
YY1 is a mammalian zinc finger transcription factor that acts as both a positive and negative regulator of transcription at CCATNTT consensus DNA elements in promoters of cellular and viral genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC210Hu01 Recombinant Histone Deacetylase 2 (HDAC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPC210Hu02 Recombinant Histone Deacetylase 2 (HDAC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC210Hu01 Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) WB; IHC; ICC; IP.
MAC210Hu22 Monoclonal Antibody to Histone Deacetylase 2 (HDAC2) WB; IHC; ICC; IP.
Assay Kits SEC210Hu ELISA Kit for Histone Deacetylase 2 (HDAC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC210Mu01 Recombinant Histone Deacetylase 2 (HDAC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPC210Mu02 Recombinant Histone Deacetylase 2 (HDAC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC210Mu01 Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) WB; IHC; ICC; IP.
PAC210Mu02 Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) WB; IHC; ICC; IP.
Assay Kits SEC210Mu ELISA Kit for Histone Deacetylase 2 (HDAC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC210Ra01 Recombinant Histone Deacetylase 2 (HDAC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC210Ra01 Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) WB; IHC; ICC; IP.
MAC210Ra21 Monoclonal Antibody to Histone Deacetylase 2 (HDAC2) WB; IHC; ICC; IP.
Assay Kits SEC210Ra ELISA Kit for Histone Deacetylase 2 (HDAC2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3."Proc. Natl. Acad. Sci. U.S.A. 93:12845-12850(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4."Biochemistry 38:14711-14717(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A role for SKIP in EBNA2 activation of CBF1-repressed promoters."J. Virol. 74:1939-1947(2000) [PubMed] [Europe PMC] [Abstract]
  7. "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci."Nat. Genet. 25:269-277(2000) [PubMed] [Europe PMC] [Abstract]
  8. "NuRD and SIN3 histone deacetylase complexes in development."Trends Genet. 16:351-356(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation."Genes Dev. 15:1140-1151(2001) [PubMed] [Europe PMC] [Abstract]
  10. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation and characterization of a novel class II histone deacetylase, HDAC10."J. Biol. Chem. 277:6656-6666(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2."J. Biol. Chem. 277:35783-35786(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek."J. Cell Sci. 115:3319-3330(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Acetylation inactivates the transcriptional repressor BCL6."Nat. Genet. 32:606-613(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene."EMBO J. 22:6299-6309(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
  17. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Identification and characterization of three new components of the mSin3A corepressor complex."Mol. Cell. Biol. 23:3456-3467(2003) [PubMed] [Europe PMC] [Abstract]
  19. "The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains."J. Biol. Chem. 279:50930-50941(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein."J. Biol. Chem. 280:28507-28518(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  23. "SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus."Nucleic Acids Res. 34:3288-3298(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  25. "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation."Mol. Cell 32:718-726(2008) [PubMed] [Europe PMC] [Abstract]
  26. "CtBP is an essential corepressor for BCL6 autoregulation."Mol. Cell. Biol. 28:2175-2186(2008) [PubMed] [Europe PMC] [Abstract]
  27. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  28. "RCS1, a substrate of APC/C, controls the metaphase to anaphase transition."Proc. Natl. Acad. Sci. U.S.A. 105:13415-13420(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  30. "FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4."PLoS ONE 4:E5071-E5071(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Chfr is linked to tumour metastasis through the downregulation of HDAC1."Nat. Cell Biol. 11:295-302(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  35. "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
  36. "Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1."Mol. Cell 42:285-296(2011) [PubMed] [Europe PMC] [Abstract]
  37. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  38. "RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene."Oncogene 32:3711-3721(2013) [PubMed] [Europe PMC] [Abstract]
  39. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  40. "The subcellular distribution and function of MTA1 in cancer differentiation."Oncotarget 5:5153-5164(2014) [PubMed] [Europe PMC] [Abstract]
  41. "Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides."Bioorg. Med. Chem. Lett. 20:3142-3145(2010) [PubMed] [Europe PMC] [Abstract]