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Ring Finger Protein 4 (RNF4)

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RES4-26; SNURF; E3 ubiquitin-protein ligase RNF4; Small nuclear ring finger protein

Ring Finger Protein 4 (RNF4)
CCC C217
HGNC 10067
MGI 1201691
PubMed 23197296
RGD 3583
UniProt P78317
Wiki RNF4
RING finger protein 4 contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.
The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 4 (RNF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 4 (RNF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 4 (RNF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 4 (RNF4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC217Mu01 Recombinant Ring Finger Protein 4 (RNF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 4 (RNF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 4 (RNF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 4 (RNF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 4 (RNF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 4 (RNF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 4 (RNF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 4 (RNF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 4 (RNF4) ELISA Kit Customized Service Offer
  1. "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3."DNA Res. 5:177-186(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3."Genomics 47:258-265(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor."J. Biol. Chem. 275:7894-7901(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."J. Biol. Chem. 278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]
  8. "SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies."Exp. Cell Res. 304:224-233(2005) [PubMed] [Europe PMC] [Abstract]
  9. "RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation."Nat. Cell Biol. 10:538-546(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "PARP-1 transcriptional activity is regulated by sumoylation upon heat shock."EMBO J. 28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3."Mol. Cell. Biol. 29:3204-3218(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The SUMO protease SENP6 is essential for inner kinetochore assembly."J. Cell Biol. 188:681-692(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies."Mol. Biol. Cell 21:4227-4239(2010) [PubMed] [Europe PMC] [Abstract]
  16. "RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha."Nucleic Acids Res. 38:1922-1931(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms."PLoS ONE 7:E44949-E44949(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the RING domain of the human RING finger protein 4."Submitted (JUL-2007) to the PDB data bank