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Actinin Alpha 4 (ACTN4)

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FSGS; FSGS1; F-actin cross-linking protein; Non-muscle alpha-actinin 4

Actinin Alpha 4 (ACTN4)
CCC C223
HGNC 166
MGI 1890773
PubMed 22348389
RGD 61816
UniProt O43707
Wiki ACTN4
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Alpha-actinin-4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC223Hu01 Recombinant Actinin Alpha 4 (ACTN4) Positive Control; Immunogen; SDS-PAGE; WB.
RPC223Hu02 Recombinant Actinin Alpha 4 (ACTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC223Hu01 Polyclonal Antibody to Actinin Alpha 4 (ACTN4) WB,IHC
MAC223Hu21 Monoclonal Antibody to Actinin Alpha 4 (ACTN4) WB; IHC; ICC; IP.
PAC223Hu02 Polyclonal Antibody to Actinin Alpha 4 (ACTN4) WB; IHC; ICC; IP.
Assay Kits SEC223Hu ELISA Kit for Actinin Alpha 4 (ACTN4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actinin Alpha 4 (ACTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actinin Alpha 4 (ACTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actinin Alpha 4 (ACTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actinin Alpha 4 (ACTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actinin Alpha 4 (ACTN4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actinin Alpha 4 (ACTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actinin Alpha 4 (ACTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actinin Alpha 4 (ACTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actinin Alpha 4 (ACTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actinin Alpha 4 (ACTN4) ELISA Kit Customized Service Offer
  1. "The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells."Oncogene 19:380-386(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431."Tsitologiia 54:25-32(2012) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion."J. Cell Biol. 140:1383-1393(1998) [PubMed] [Europe PMC] [Abstract]
  8. ErratumJ. Cell Biol. 143:276-276(1998)
  9. "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]
  10. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors."J. Biol. Chem. 287:12027-12035(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis."Nat. Genet. 24:251-256(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism."Am. J. Kidney Dis. 51:834-838(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Mutational analysis of ACTN4, encoding alpha-actinin 4, in patients with focal segmental glomerulosclerosis using HRM method."Folia Biol. (Praha) 59:110-115(2013) [PubMed] [Europe PMC] [Abstract]