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Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1)

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PTP1B; PTP1-B; Protein-tyrosine phosphatase 1B

Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1)
CCC C226
HGNC 9642
MGI 97805
PubMed 24531327
RGD 61965
UniProt P18031
Wiki PTPN1
Tyrosine-protein phosphatase non-receptor type 1 is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity.
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC226Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC226Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) WB; IHC; ICC; IP.
MAC226Hu21 Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) WB; IHC; ICC; IP.
Assay Kits SEC226Hu ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) ELISA Kit Customized Service Offer
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  9. "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B."J. Biol. Chem. 274:26697-26704(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor."Mol. Endocrinol. 15:1768-1780(2001) [PubMed] [Europe PMC] [Abstract]
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  14. "PTP1B regulates Eph receptor function and trafficking."J. Cell Biol. 191:1189-1203(2010) [PubMed] [Europe PMC] [Abstract]
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  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response."Sci. Signal. 4:RA86-RA86(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of human protein tyrosine phosphatase 1B."Science 263:1397-1404(1994) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design."Proc. Natl. Acad. Sci. U.S.A. 94:13420-13425(1997) [PubMed] [Europe PMC] [Abstract]
  21. "Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by X-ray crystallography."J. Biol. Chem. 273:10454-10462(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics."Biochemistry 37:17773-17783(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate."Nature 423:769-773(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B."Nature 423:773-777(2003) [PubMed] [Europe PMC] [Abstract]
  25. "Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism."Obes. Res. 13:829-834(2005) [PubMed] [Europe PMC] [Abstract]