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G Protein Alpha Z (GNaZ)

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GN-AZ; Guanine Nucleotide Binding Protein Alpha Z; G(x) alpha chain

G Protein Alpha Z (GNaZ)
CCC C230
HGNC 4395
MGI 95780
PubMed 9856474
RGD 2717
UniProt P19086
Wiki GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
By in situ hybridization, Wilkie et al. (1992) demonstrated that the GNAZ gene is located in band 22q11. By the analysis of RFLVs in an interspecific backcross, they showed that the corresponding gene is located on mouse chromosome 10. Budarf et al. (1991) further narrowed the localization to 22q11.2 by fluorescence in situ hybridization on reverse banded metaphase chromosomes. They confirmed the localization by means of a regional mapping panel of somatic cell hybrids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC230Hu01 Recombinant G Protein Alpha Z (GNaZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC230Hu01 Polyclonal Antibody to G Protein Alpha Z (GNaZ) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for G Protein Alpha Z (GNaZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Alpha Z (GNaZ) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Alpha Z (GNaZ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Alpha Z (GNaZ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Alpha Z (GNaZ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Alpha Z (GNaZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Alpha Z (GNaZ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Alpha Z (GNaZ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Alpha Z (GNaZ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Alpha Z (GNaZ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Alpha Z (GNaZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Alpha Z (GNaZ) ELISA Kit Customized Service Offer
  1. "Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin."Proc. Natl. Acad. Sci. U.S.A. 85:3066-3070(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein."J. Biol. Chem. 265:13215-13220(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes."Blood 78:1247-1253(1991) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]