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Zyxin (ZYX)

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ESP2; HED2

Zyxin (ZYX)
CCC C235
HGNC 13200
MGI 103072
PubMed 10831611
RGD 620698
UniProt Q15942
Wiki Zyxin

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC235Hu01 Recombinant Zyxin (ZYX) Positive Control; Immunogen; SDS-PAGE; WB.
RPC235Hu02 Recombinant Zyxin (ZYX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC235Hu01 Polyclonal Antibody to Zyxin (ZYX) WB; IHC; ICC; IP.
PAC235Hu02 Polyclonal Antibody to Zyxin (ZYX) WB; IHC; ICC; IP.
LAC235Hu71 Biotin-Linked Polyclonal Antibody to Zyxin (ZYX) WB; IHC; ICC.
LAC235Hu81 FITC-Linked Polyclonal Antibody to Zyxin (ZYX) WB; IHC; ICC; IF.
MAC235Hu21 Monoclonal Antibody to Zyxin (ZYX) WB; IHC; ICC; IP.
Assay Kits SEC235Hu ELISA Kit for Zyxin (ZYX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zyxin (ZYX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zyxin (ZYX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zyxin (ZYX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zyxin (ZYX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zyxin (ZYX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zyxin (ZYX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zyxin (ZYX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zyxin (ZYX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zyxin (ZYX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zyxin (ZYX) ELISA Kit Customized Service Offer
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  7. , Submitted (FEB-2008) to UniProtKB
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  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]