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Replication Factor C1 (RFC1)

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A1; MHCBFB; PO-GA; RECC1; RFC; RFC140; Activator 1 140 kDa subunit; DNA-binding protein PO-GA; Replication factor C 140 kDa subunit; Replication factor C large subunit

Replication Factor C1 (RFC1)
CCC C237
HGNC 9969
MGI 97891
PubMed 11162445
RGD 620619
UniProt P35251
Wiki RFC1

Replication factor C subunit 1 is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.

Replication factor C is a multisubunit, DNA polymerase accessory protein required for the coordinated synthesis of both DNA strands during simian virus 40 DNA replication in vitro. It is a DNA-dependent ATPase that binds in a structure-specific manner to the 3-prime end of a primer hybridized to a template DNA, an activity thought intrinsic to the 140-kD component of this multisubunit complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Factor C1 (RFC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Factor C1 (RFC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C1 (RFC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C1 (RFC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C1 (RFC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Factor C1 (RFC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Factor C1 (RFC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C1 (RFC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C1 (RFC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C1 (RFC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Factor C1 (RFC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Factor C1 (RFC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C1 (RFC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C1 (RFC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C1 (RFC1) ELISA Kit Customized Service Offer
  1. "cDNAs encoding the large subunit of human replication factor C."Proc. Natl. Acad. Sci. U.S.A. 90:11014-11018(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of a novel human DNA binding protein, PO-GA."Biochem. Biophys. Res. Commun. 193:779-786(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA."Gene 145:261-265(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen."J. Biol. Chem. 272:1769-1776(1997) [PubMed] [Europe PMC] [Abstract]
  7. "DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C."Nucleic Acids Res. 26:3877-3882(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the BRCT domain from human replication factor C large subunit 1."Submitted (AUG-2007) to the PDB data bank