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Deoxyribonuclease II (DNASEII)

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DNase-II; DNase2; DNASE2A; DNASE2B; DRN2; DNL; DNL2; Deoxyribonuclease II Alpha; Acid DNase; Lysosomal DNase II

Deoxyribonuclease II (DNASEII)
CCC C247
HGNC 2960
MGI 1329019
PubMed 14644493
RGD 621457
UniProt O00115
Wiki DNASEII

Deoxyribonuclease II, or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA yielding products with 3'-phosphates. As the name implies, it is more effective at acid pHs.

There are several known DNases II, including:DNase II alpha (usually just called DNase II) ;DNase II beta (also called DLAD, or DNase II-Like Acid DNase)The predicted 360-amino acid protein has 3 parts: a 16-amino acid signal peptide, a 91-amino acid propeptide, and a 253-amino acid mature protein region. like other lysosomal enzymes, DNase II is processed by release of a signal peptide followed by proteolytic processing that generates a 2-chain enzyme. Purified DNase II migrates as 2 bands (32 and 12 kD) on SDS-PAGE.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC247Hu01 Recombinant Deoxyribonuclease II (DNASEII) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC247Hu01 Polyclonal Antibody to Deoxyribonuclease II (DNASEII) WB; IHC; ICC; IP.
Assay Kits SEC247Hu ELISA Kit for Deoxyribonuclease II (DNASEII) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxyribonuclease II (DNASEII) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxyribonuclease II (DNASEII) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxyribonuclease II (DNASEII) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deoxyribonuclease II (DNASEII) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxyribonuclease II (DNASEII) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxyribonuclease II (DNASEII) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxyribonuclease II (DNASEII) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxyribonuclease II (DNASEII) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deoxyribonuclease II (DNASEII) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxyribonuclease II (DNASEII) ELISA Kit Customized Service Offer
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  2. "Cloning of cDNAs encoding porcine and human DNase II."Biochem. Biophys. Res. Commun. 247:864-869(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of human and murine DNase II."Gene 215:281-289(1998) [PubMed] [Europe PMC] [Abstract]
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  9. "Revised structure of the active form of human deoxyribonuclease IIalpha."Biochem. Biophys. Res. Commun. 292:415-421(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging."Biochem. J. 371:867-876(2003) [PubMed] [Europe PMC] [Abstract]
  11. "A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei."Gene 305:1-12(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]